42445-55-6 Usage
Uses
Used in Pharmaceutical Industry:
2-Chloro-1-(5-chlorothiophen-2-yl)ethanone is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloro-1-(5-chlorothiophen-2-yl)ethanone is utilized as an intermediate in the production of agrochemicals. Its properties allow for the creation of compounds that can be used in pest control and crop protection.
Used in Organic Synthesis:
2-Chloro-1-(5-chlorothiophen-2-yl)ethanone is employed as a reactant in organic synthesis processes. Its reactivity and structural features make it a useful building block for the creation of complex organic molecules.
Used in Drug Discovery Research:
2-Chloro-1-(5-chlorothiophen-2-yl)ethanone is used as a research tool in drug discovery, where its unique properties can be explored for the development of novel therapeutic agents. Its potential applications in this field highlight the importance of understanding and harnessing its reactivity in controlled laboratory settings.
It is crucial to handle 2-Chloro-1-(5-chlorothiophen-2-yl)ethanone with care, as it is a potentially hazardous chemical. Appropriate safety measures should be in place when working with 2-Chloro-1-(5-chlorothiophen-2-yl)ethanone to ensure the safety of researchers and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 42445-55-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,4,4 and 5 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 42445-55:
(7*4)+(6*2)+(5*4)+(4*4)+(3*5)+(2*5)+(1*5)=106
106 % 10 = 6
So 42445-55-6 is a valid CAS Registry Number.
42445-55-6Relevant academic research and scientific papers
Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools
Perez, Daniel I.,Conde, Santiago,Perez, Concepcion,Gil, Carmen,Simon, Diana,Wandosell, Francisco,Moreno, Francisco J.,Gelpi, Jose L.,Luque, Francisco J.,Martinez, Ana
scheme or table, p. 6914 - 6925 (2010/02/28)
Thienylhalomethylketones, whose chemical, biological, and pharmaceutical data are here reported, are the first irreversible inhibitors of GSK-3β described to date. Their inhibitory activity is likely related to the cysteine residue present in the ATP-binding site, which is proposed as a relevant residue for modulation of GSK-3 activity. The good cell permeability of the compounds allows them to be used in different cell models. Overall, the results presented here support the potential use of halomethylketones as pharmacological tools for the study of GSK-3β functions and suggest a new mechanism for GSK-3β inhibition that may be considered for further drug design.
Thienyl and Phenyl α-Halomethyl Ketones: New Inhibitors of Glycogen Synthase Kinase (GSK-3β) from a Library of Compound Searching
Conde, Santiago,Pérez, Daniel I.,Martínez, Ana,Perez, Concepción,Moreno, Francisco J.
, p. 4631 - 4633 (2007/10/03)
Glycogen synthase kinase (GSK-3β) plays a crucial role in Alzheimer's disease (AD). Its inhibition is a valid approach to the treatment of AD. In this initial letter, some thienyl and phenyl α-halomethyl ketones are described as new non-ATP competitive inhibitors of GSK-3β. They are considered as lead compounds for designing and synthesizing new series, to carry out SAR studies, clear up the mechanism of action, and, in general, evaluate their therapheutical usefulness.
