71683-01-7

Basic information

• Product Name: 3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE
• Synonyms: 3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE;3-(5-Chlorothiophen-2-yl)-3-oxopropanenitrile;3-(5-Chloro-2-thienyl)-3-oxopropanenitrile;5-Chloro-2-thenoylacetonitrile;5-Chloro-beta-oxo-2-thiophenepropanenitrile
• CAS NO: 71683-01-7
• Molecular Formula: C7H4ClNOS
• Molecular Weight: 185.63
• Mol File: 71683-01-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.403
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE(71683-01-7)
• EPA Substance Registry System: 3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE(71683-01-7)

Safety Data

• Hazardous Substances Data: 71683-01-7(Hazardous Substances Data)

Usage

General Description

3-(5-chloro-thiophen-2-yl)-3-oxo-propionitrile is a chemical compound with the molecular formula C7H3ClNO2S. It is a nitrile compound that contains a chloro-thiophene ring and a propionitrile functional group. 3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including antimicrobial and antiviral properties. The presence of both a chloro and a thiophene group in its structure makes this compound particularly useful for its reactivity in synthetic chemistry, contributing to its wide range of applications in various industries.

Upstream product

• 35475-03-7 methyl 5-chloro-2-thiophenecarboxylate 
• 75-05-8 acetonitrile 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 6310-09-4 2-acetyl-5-chlorothiophene 
• 42445-55-6 2-chloro-1-(5-chlorothiophen-2-yl)ethan-1-one 
• 151-50-8 potassium cyanide 

Relevant articles and documents

Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors

The transcriptional regulator FUSE binding protein 1 (FUBP1) is aberrantly upregulated in various malignancies, fulfilling its oncogenic role by the deregulation of critical genes involved in cell cycle control and apoptosis regulation. Thus, the pharmaceutical inhibition of this protein would represent an encouraging novel targeted chemotherapy. Here, we demonstrate the identification and initial optimization of a pyrazolo[1,5a]pyrimidine-based FUBP1 inhibitor derived from medium throughput screening, which interferes with the binding of FUBP1 to its single stranded target DNA FUSE. We were able to generate a new class of FUBP1 interfering molecules with in vitro and biological activity. In biophysical assays, we could show that our best inhibitor, compound 6, potently inhibits the binding of FUBP1 to the FUSE sequence with an IC50value of 11.0 μM. Furthermore, hepatocellular carcinoma cells exhibited sensitivity towards the treatment with compound 6, resulting in reduced cell expansion and induction of cell death. Finally, we provide insights into the corresponding SAR landscape, leading to a prospective enhancement in potency and cellular efficacy.