42461-91-6

Basic information

• Product Name: (2E)-3-(1,3-benzodioxol-5-yl)prop-2-en-1-yl acetate
• CAS NO: 42461-91-6
• Molecular Formula: C₁₂H₁₂O₄
• Molecular Weight: 220.2213
• Mol File: 42461-91-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 362.6°C at 760 mmHg
• Flash Point: 162.2°C
• Density: 1.236g/cm³
• Vapor Pressure: 1.92E-05mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: (2E)-3-(1,3-benzodioxol-5-yl)prop-2-en-1-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(1,3-benzodioxol-5-yl)prop-2-en-1-yl acetate(42461-91-6)
• EPA Substance Registry System: (2E)-3-(1,3-benzodioxol-5-yl)prop-2-en-1-yl acetate(42461-91-6)

Safety Data

• Hazardous Substances Data: 42461-91-6(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 108-24-7 acetic anhydride 
• 17581-86-1 3-(benzo[1,3]dioxol-5-yl)prop-2-en-1-ol 
• 14731-78-3 ethyl 3,4-methylenedioxycinnamate 
• 100-52-7 benzaldehyde 
• 24393-66-6 ethyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate 
• 64-19-7 acetic acid 
• 58095-76-4 (E)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-ol 
• 591-87-7 Allyl acetate 
• 274-09-9 Methylenedioxybenzene 
• 94-59-7 1-allyl-3,4-methylenedioxybenzene 

Downstream Products

• 112778-61-7 (4R,5S)-4-Acetoxymethyl-5-benzo[1,3]dioxol-5-yl-2-(3,4-dimethoxy-phenyl)-4,5-dihydro-furan-3-carboxylic acid ethyl ester 

Relevant articles and documents

Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity

In the presence of a neutral dppf-modified iridium catalyst and Cs2CO3, linear allylic acetates react with primary amines to form products of hydroamination with complete 1,3-regioselectivity. The collective data, including deuterium labeling studies, corroborate a catalytic mechanism involving rapid, reversible acetate-directed aminoiridation with inner-sphere/outer-sphere crossover followed by turnover-limiting proto-demetalation mediated by amine.

Palladium-catalyzed diastereoselective synthesis of homoaldol equivalent products

A palladium-catalyzed reaction of easily accessible 3-(pinacolatoboryl)allyl acetates and aldehydes provides facile access to synthetically useful homoaldol equivalent products with high diastereoselectivity. The reaction presumably proceeds via allylation of aldehydes with α-acetoxy allylboronates that produced in situ by reductive elimination from allylic gem-palladium/boryl intermediates.

NOVEL PIPERINE DERIVATIVES AND USES THEREOF

The present invention provides novel piperine derivatives. The present pharmaceutical or food composition containing a piperine derivative as an active ingredient is very effective in preventing or treating metabolic diseases including obesity, diabetes, dyslipidemia, fatty liver and insulin resistance syndrome. Piperine derivatives of the present invention useful as pharmaceuticals compositions or functional food compositions has therapeutic efficacies for metabolic syndrome selected from the group consisting of obesity, diabetes, hyperlipidemia, fatty liver and insulin resistance syndrome, and also suppress the differentiation of progenitor cells and reduce the accumulation of triglycerides.