42484-83-3

Basic information

• Product Name: 5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 7-methyl-2-phenyl-
• CAS NO: 42484-83-3
• Molecular Formula: C12H9N3OS
• Molecular Weight: 243.289
• Mol File: 42484-83-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 7-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 7-methyl-2-phenyl-(42484-83-3)
• EPA Substance Registry System: 5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 7-methyl-2-phenyl-(42484-83-3)

Safety Data

• Hazardous Substances Data: 42484-83-3(Hazardous Substances Data)

Upstream product

• 5351-66-6 benzoyl thiosemicarbazide 
• 141-97-9 ethyl acetoacetate 
• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 65-85-0 benzoic acid 
• 35523-72-9 1-amino-4-methyl-6-oxo-2(3H)-pyrimidinethione 
• 75045-89-5 3-oxo-N-(5-phenyl-1,3,4-thiadiazol-2-yl)butanamide 
• 1752-30-3 Acetone thiosemicarbazone 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Relevant articles and documents

Convenient Synthesis of 2,7-Disubstituted 5H-1,3,4-Thiadiazolopyrimidin-5-ones and Related Compounds

2,7-Disubstituted 5H-1,3,4-thiadiazolopyrimidin-5-ones were synthesized from the reaction of 3-amino-6-methyl-2-thiouracil with carboxylic acid or from that of thiosemicarbazide with carboxylic acid and β-keto ester in the presence of phosphorus pentaoxide and methanesulfonic acid.The synthesis of related compounds is also described.

Reaction of β-Keto Esters with 2-Amino-1,3,4-thiadiazoles. A Reinvestigation

2-Amino-5-substituted-1,3,4-thiadiazoles react with ethyl acetoacetate under basic conditions to give 3-oxo-N-(5-substituted-1,3,4-thiadiazol-2-yl)butanamides 4.During acid cyclization, 4 rearranges to give a mixture of thiadiazolopyrimidones 3 and 5, the ratio varying with the nature of the substituents.Under acidic conditions, the butenoic ester 2 can also be isolated; however, it does not rearrange and yields only the expected 3.With ethyl benzoylacetate under acidic and basic conditions, only one compound is formed whose structure was determined as the enol form of 4d by X-ray diffraction.In strong acid, it also cyclizes and rearranges to give a mixture of 3 and 5 in a 9:1 ratio.