425-87-6

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER is used as a solvent for the synthesis of various pharmaceutical compounds due to its ability to dissolve a wide range of substances, facilitating chemical reactions necessary for drug production.
Used in Agrochemical Industry:
In the agrochemical sector, 2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER is utilized as a solvent in the manufacturing process of pesticides and other agricultural chemicals, contributing to the efficiency of these products in their intended applications.
Used as a Chemical Intermediate:
2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER also serves as an intermediate in the synthesis of other chemicals, playing a crucial role in the production of a variety of compounds used across different industries.

InChI:InChI=1/C3H4ClF3O/c1-8-3(6,7)2(4)5/h2H,1H3

Upstream product

• 67-56-1 methanol 
• 79-38-9 Chlorotrifluoroethylene 
• 124-41-4 sodium methylate 
• 76-13-1 1,1,2-Trichloro-1,2,2-trifluoroethane 

Downstream Products

• 428-92-2 2-chloro-1,1,2-trifluoroethyl chloromethyl ether 
• 428-96-6 (2-chloro-1,1,2-trifluoroethyl)dichloromethylether 
• 460-99-1 (2-chloro-1,1,2-trifluoroethyl)trichloromethylether 
• 428-73-9 (2,2-dichloro-1,1,2-trifluoroethyl)trichloromethylether 
• 116-54-1 dichloroacetic acid methyl ester 
• 32776-56-0 2,2-dichloro-1,1,2-trifluoroethyl chloromethyl ether 
• 74-87-3 methylene chloride 
• 593-53-3 Methyl fluoride 
• 359-34-2 chlorofluoroacetyl fluoride 
• 29771-98-0 dichloromethyl(2,2-dichloro-1,1,2-trifluoroethyl)ether 

Relevant academic research and scientific papers

RADICAL REDUCTION OF C-Cl BONDS IN CHLOROFLUORO ETHERS

Reduction of C-Cl bonds in 2,2-dichloro-1,1,2-trifluoroethyl trichloromethyl ether (I), 2-chloro-1,1,2-trifluoroethyl trichloromethyl ether (II), and 2,2-dichloro-1,1,2-trifluoroethyl dichloromethyl ether (III) with 2-propanol, 2-butanol, cyclohexanol, tetrahydrofuran, diethyl ether, and 1,3-dioxolane initiated photochemically and by radiation has been investigated.Beside the main reduction products - 2-chloro-1,1,2-trifluoroethyl dichloromethyl ether (IV) and 2-chloro-1,1,2-trifluoroethyl chloromethyl ether (V) - it was also possible to prove the formation of 1,2-dichloro-1,2-bis(2-chloro-1,1,2-trifluoroethoxyethane) (VI), 1-chloro-1,2-bis(2-chloro-1,1,2-trifluoroethoxy)ethene (VII), and 1,2-dichloro-1,2-bis(2-chloro-1,1,2-trifluoroethoxy)ethene (VIII).The structure of products was confirmed by elemental analysis, MS, IR, 1H NMR and 19F NMR spectra and by GLC comparison of the elution times with those of the standards.The relative reduction ability of the solvents used and the reduction rate order of C-Cl bonds in the compounds (CCl3 > CFCl2 > CHCl2 and CFClH) are given.

A Facile Synthesis of Fluorochlorobromoacetic Acid

Fluorochlorobromoacetic acid was synthesized in the sequence of four steps from 1,1,2-trifluoro-2-chloroethylene in an overall yield of approximately 25percent. 1,1,2-Trifluoro-2-chloroethylene was first allowed to react with sodium methoxide to form 1,2-difluoro-1-chloro-2-methoxyethylene, which was then brominated with elemental bromine and the reaction product treated with concentrated sulfuric acid to give methyl fluorochlorobromoacetate.This compound was hydrolized with a diluted sodium hydroxide solution to fluorochlorobromoacetic acid.

Enthalpies of vaporization and cohesive energies of 2-chloro-1,1,2-trifluoroethyl methyl ether, 2-chloro-1,1,2-trifluoroethyl isopropyl ether, 2-chloro-1,1,2-trifluoroethyl butyl ether, and 2-chloro-1,1,2-trifluoroethyl chlorofluoromethyl ether

The temperature dependences of molar enthalpies of vaporization of four chlorofluoroethers were measured calorimetrically with an accuracy of 0.3 per cent.The compounds and the temperature ranges of measurement were: 2-chloro-1,1,2-trifluoroethyl methyl ether, 298.15 to 343.15 K; 2-chloro-1,1,2-trifluoroethyl isopropyl ether, 298.15 to 328.15 K; 2-chloro-1,1,2-trifluoroethyl butyl ether, 298.15 to 368.15 K; 2-chloro-1,1,2-trifluoroethyl chlorofluoromethyl ether, 298.15 to 368.15 K.The results were correlated as a function of temperature, and molar cohesive energies were evaluated.