425392-56-9

Usage

Structure

Thiazole ring, two phenyl groups, and a carboxylic acid group The compound consists of a five-membered thiazole ring, two phenyl groups (aromatic rings with a hydrogen atom attached to each carbon), and a carboxylic acid group (a carbonyl group bonded to a hydroxyl group).

Application

Pharmaceutical industry 2,5-diphenylthiazole-4-carboxylic acid is primarily used in the pharmaceutical industry due to its potential biological activities and drug development capabilities.

Anti-cancer properties

Inhibits cancer cell growth The compound has been studied as a potential anti-cancer agent and has shown promising results in inhibiting the growth of cancer cells in in vitro studies.

Antimicrobial properties

Potential use in treating infections 2,5-diphenylthiazole-4-carboxylic acid has been investigated for its antimicrobial properties, making it a potentially useful compound for the development of new drugs to treat various infections.

Anti-inflammatory properties

Potential use in treating inflammation-related conditions The compound has also been studied for its anti-inflammatory properties, which could make it useful in the development of new drugs to treat various inflammation-related conditions.

Upstream product

• 161198-41-0 ethyl 2,5-diphenyl-4-thiazolecarboxylate 
• 133415-16-4 methyl 2,5-diphenylthiazole-4-carboxylate 
• 2227-79-4 benzenecarbothioamide 
• 1198280-54-4 3-(perfluorooctyl)propyl 2,5-diphenylthiazole-4-carboxylate 
• 6476-17-1 ethyl 3-bromo-2-oxo-3-phenylpropionate 
• 98-80-6 phenylboronic acid 
• 425392-46-7 5-chloro-2-phenylthiazole-4-carboxylic acid ethyl ester 

Downstream Products

• 1198280-65-7 (S)-benzyl 2-(2,5-diphenylthiazole-4-carboxamido)-3-methylbutanoate 
• 2104-11-2 2,4,5-triphenylthiazole 
• 3704-40-3 2,5-diphenyl-1,3-thiazole 

Relevant academic research and scientific papers

Solution versus fluorous versus solid-phase synthesis of 2,5-disubstituted 1,3-azoles. Preliminary antibacterial activity studies

(Chemical Equation Presented) A small library of compounds with an oxa(thia)zole scaffold and structural diversity in both positions 2 and 5 has been synthesized. Double acylation of a protected glycine affords intermediate α-amido-β-ketoesters, which in turn can be dehydrated to afford 1,3-oxazoles or reacted with Lawesson's reagent to furnish 1,3-thiazoles. This procedure was designed with its adaptation to fluorous techniques in mind. Thus, when a protected glycine with a fluorous tag in the ester moiety is used as a starting material, the synthesis can be easily completed without column chromatography purification of intermediate compounds with good to excellent yields, thus affording a suitable entry to the preparation of small libraries of these bioactive compounds. The prepared oxa(thia)zoles were assayed for their antibacterial activity, and several of them were active against Staphylococcus aureus.

Fused polycyclic nitrogen-containing heterocycles: VIII. Friedel-Crafts intramolecular cyclization of 5-phenylthiazole-4-carboxylic acids - A new route to indeno[2,1-d]thiazoles

Friedel-Crafts intramolecular cyclization in the presence of polyphosphoric acid of 2-substituted 5-phenylthiazole-4-carboxylic acids, which are obtained by alkaline hydrolysis of the corresponding esters, leads to indeno[2,1-d]thiazoles. According to the

Regiocontrolled Synthesis of Substituted Thiazoles

(Formula Presented) The regiocontrolled synthesis of 2,5-disubstituted and 2,4,5-trisubstituted thiazoles from ethyl 2-bromo-5-chloro-4-thiazolecarboxylate 1 using sequential palladium-catalyzed coupling reactions is described.