4254-63-1Relevant academic research and scientific papers
The reaction studies of α-chloroformylarylhydrazines with thiols, thioureas and α-cyclodiketones
Kuo, Wen-Fa,Wu, Ming-Shyue,Chiu, Chun-Yen,Yeh, Mou-Yung
, p. 215 - 228 (2007/10/03)
The reactions of α-chloroformylarylhydrazines 1 with various types of mercaptan, thiourea and α-cyclodiketone have been studied intensively. 1-Arylhydrazinecarbothioates 2 were obtained via thioesterization when α-chloroformylarylhydrazines reacted with thiols. On the other hand, compounds 3 were obtained when α-chloroformylarylhydrazines reacted with thio-containing heterocyclic compounds, which suggested a totally different mechanism in these types of reactions. Further studies on the reaction of α-chloroformylarylhydrazines 1 with thiourea compounds confirmed a novel cyclization and de-cyclization mechanism, which led to give 2-arylhydrazinecarboximidamides 5 and 1,3,4-thiadiazolin-5-ones 6. In addition, various 1,3,4-oxadiazines 9 were obtained by reacting α-chloroformylarylhydrazines with α-cyclodiketones, showing ring cyclization was involved in this type of reaction.
