14575-59-8

Basic information

• Product Name: 1-phenyl-1H-1,2,4-triazole-3,5-diamine
• Synonyms: 1-phenyl-1H-1,2,4-triazole-3,5-diamine;Phenylguanazole
• CAS NO: 14575-59-8
• Molecular Formula: C8H9N5
• Molecular Weight: 175.19056
• EINECS: 238-615-3
• Mol File: 14575-59-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 450.1°C at 760 mmHg
• Flash Point: 226°C
• Appearance: /
• Density: 1.48g/cm³
• Vapor Pressure: 2.71E-08mmHg at 25°C
• Refractive Index: 1.752
• CAS DataBase Reference: 1-phenyl-1H-1,2,4-triazole-3,5-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-1H-1,2,4-triazole-3,5-diamine(14575-59-8)
• EPA Substance Registry System: 1-phenyl-1H-1,2,4-triazole-3,5-diamine(14575-59-8)

Safety Data

• Hazardous Substances Data: 14575-59-8(Hazardous Substances Data)

Usage

General Description

1-phenyl-1H-1,2,4-triazole-3,5-diamine is a chemical compound with the molecular formula C9H9N5. It is a white to light yellow solid with a molecular weight of 179.20 g/mol. 1-phenyl-1H-1,2,4-triazole-3,5-diamine is used in the production of pharmaceuticals and agrochemicals, as well as in organic synthesis as a building block for various other chemicals. It functions as a triazole fungicide, herbicide and antifungal agent. It is also used as a reagent in organic synthesis and as an intermediate in the production of dyes and pigments. Additionally, it has been shown to have potential anti-cancer and anti-tumor properties. Overall, 1-phenyl-1H-1,2,4-triazole-3,5-diamine is a versatile compound with a wide range of applications.

InChI:InChI=1/C8H9N5/c9-7-11-8(10)13(12-7)6-4-2-1-3-5-6/h1-5H,(H4,9,10,11,12)

Upstream product

• 56-03-1 BIGUANIDE 
• 100-63-0 phenylhydrazine 
• 127099-85-8 N-Cyanoguanidine 
• 1228305-28-9 ethyl 3-(5-amino-1-phenyl-1H-1,2,4-triazol-3-ylamino)but-2-enoate 
• 59-88-1 phenylhydrazine hydrochloride 
• 124-46-9 guanidine hydrogen carbonate 
• 4254-63-1 anilino-guanidine; hydrochloride 
• 420-04-2 CYANAMID 

Downstream Products

• 112599-50-5 N³,N⁵-bis-(2-acetyl-3-oxo-but-1-enyl)-1-phenyl-1H-[1,2,4]triazole-3,5-diyldiamine 

Relevant articles and documents

Concise and regiospecific syntheses of tri-substituted 1,2,4-triazoles

Novel tri-substituted 1,2,4-triazoles are synthesized via complementary, regiospecific routes as part of a lead finding exercise. A key feature of one of the syntheses is recognition of an intrinsic regioselectivity toward deprotonation in the 1-phenylguanazole substrate.

ASYMMETRIC TRIAZOLE BENZAMIDE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME

The present disclosure is directed to asymmetric triazole benzamide compounds of formula (I) and formula (II), pharmaceutical compositions thereof and methods for modulating or activating a Parkin ligase The present disclosure is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase. R1, R2, R3, M1, M2, M3, L1, L2, and L3 are as defined herein.

TRIAZOLE BENZAMIDE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME

The present disclosure is directed to triazole benzamide compounds of formula (I) and formula (II), pharmaceutical compositions thereof and methods for modulating or activating a Parkin ligase The present disclosure is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase. R1, R2, R3, M1, M2, M3, L1, L2, and L3 are as defined herein.