42583-60-8

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 1122-41-4 2,4-dichlorobenzenethiol 
• 100-00-5 4-chlorobenzonitrile 
• 16271-33-3 2,4-Dichlorobenzenesulfonyl chloride 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 105837-61-4 4-(2,4-dichloro-benzenesulfonyl)-aniline; hydrochloride 
• 105456-57-3 4-(2,4-dichlorobenzenesulfonyl)phenylamine 
• 105837-69-2 4-(2,4-dichloro-phenylsulfanyl)-aniline; hydrochloride 
• 105456-69-7 2,4-dichloro-1-(4-nitrobenzenesulfonyl)benzene 

Relevant academic research and scientific papers

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Microwave-assisted Ullmann-Buchwald C-S bond formation using a copper(I) catalyst and trans-cyclohexane-1,2-diol as ligand

Microwave irradiation of a thiophenol or alkyl thiol (1 equiv.) and an aryl halide (1 equiv.) in 2-propanol at 120°C for three hours in the presence of K2CO3 (2 equiv.) as base using copper(I) iodide as catalyst (5 mol%) and trans-cyclohexane-1,2-diol (2 equiv.) as ligand provides a rapid and convenient method for C-S bond formation. The process is most efficient using thiophenol and aryl iodide precursors, both of which may contain electron-donating and electronwithdrawing groups, to give the corresponding diaryl sulfide in good to excellent yield. ARKAT-USA, Inc.

Microwave-assisted cross-coupling for the construction of diaryl sulfides

The construction of diaryl sulfides through the cross-coupling of aryl iodides and thiols in microwave heating is described. By using this method, a variety of diaryl sulfides can be prepared in a mild condition and in high yields. Deactivated 4-nitrothiophenol was effective to afford the product in 94% yield. Sterically hindered ortho-substituted aryl iodides or thiophenols provided diaryl sulfides effectively by this microwave-assisted coupling reaction.

Quantitative Structure-Activity Analysis in Dihydropteroate Synthase Inhibition by Sulfones. Comparison with Sulfanilamides

A set of 25 4'-, eight 2',4'-, and five 2',4',6'-substituted 4-aminodiphenyl sulfones were tested for their inhibitory activity on dihydropteroate synthase of Escherichia coli.Linear regression analysis shows that enzymic inhibition indices correlate well with both quantum chemical and spectroscopic descriptors of the electronic structure of the common moiety 4-NH2-C6H4-SO2 of the sulfones (the above descriptors being expressed in relation to the electronic structure of the enzyme substrate, p-aminobenzoate).Therefore, the biological activity of the sulfones can be related to the electronic structural resemblance between these inhibitors and the substrate of the target enzyme.Since a similar result was previously obtained for a wide series of sulfanilamides in their different (amidic, imidic, and anionic) forms, it appears possible to consider the antibacterial sulfones and sulfanilamides as a congeneric chemical series.On the basis of the present results, the classical theory of antimetabolites would appear to take on a quantitative and sound rationale.