42600-58-8

Upstream product

• 113149-79-4 4-dimethylaminobenzyl Co(III)(dmgH)2py 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 1703-46-4 N,N-dimethyl-4-hydroxymethylaniline 
• 75-09-2 dichloromethane 
• 18523-44-9 p-(dimethylamino)phenyl azide 
• 7782-50-5 chlorine 

Downstream Products

• 16158-89-7 N,N-dimethyl-4-(methylsulfanyl-methyl)-aniline 
• 56851-19-5 N,N-dimethyl-4-phenoxymethyl-aniline 
• 956-71-8 N,N-dimethyl-4-((phenylthio)methyl)aniline 
• 223377-42-2 (E)-1-(4-N,N-dimethylaminophenyl)-2-(2-thienyl)ethylene 
• 1210451-84-5 (4-dimethylaminobenzyl) p-tolyl sulfide 
• 1417915-64-0 (Z)-2-(5-((6-((4-(dimethylamino)benzyl)oxy)naphthalen-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid 
• 1417915-87-7 C₂₀H₁₉NO₂ 
• 1369488-99-2 4-(azidomethyl)-N,N-dimethylaniline 
• 61959-53-3 1-(4-N,N-dimethylaminobenzyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole 
• 75137-14-3 N-(4-Dimethylamino-benzyl)-N-(4-fluoro-phenyl)-benzenesulfonamide 
• 80143-70-0 N-(4-N,N-dimethylaminobenzyl)-4'-fluoroaniline 
• 13640-68-1 4-benzenesulfonylmethyl-N,N-dimethyl-aniline 
• 1443830-00-9 1-[4-(N,N-dimethylamino)benzyl]apomorphine 
• 1443762-73-9 1-[4-(N,N-dimethylamino)benzyl]apocodeine 

Relevant academic research and scientific papers

A small bifunctional chelator that modulates Aβ42 aggregation

Multifunctional compounds that can modulate amyloid-β (Aβ) aggregation and interact with metal ions hold considerable promise as therapeutic agents for Alzheimer's disease (AD). Using the copper-catalyzed azide-alkyne cycloaddition reaction, a novel bifun

Synthesis method of triazole-quinoline compound

The invention discloses a synthesis method of a triazole-quinoline compound. The triazole-quinoline compound is dimethyl-[4-(4-quinoline-2-yl-[1,2,3,]triazole-1-methylene)-phenyl]amine. The method comprises the following steps: carrying out a reduction re

Formamides as Lewis Base Catalysts in SNReactions—Efficient Transformation of Alcohols into Chlorides, Amines, and Ethers

A simple formamide catalyst facilitates the efficient transformation of alcohols into alkyl chlorides with benzoyl chloride as the sole reagent. These nucleophilic substitutions proceed through iminium-activated alcohols as intermediates. The novel method, which can be even performed under solvent-free conditions, is distinguished by an excellent functional group tolerance, scalability (>100 g) and waste-balance (E-factor down to 2). Chiral substrates are converted with excellent levels of stereochemical inversion (99 %→≥95 % ee). In a practical one-pot procedure, the primary formed chlorides can be further transformed into amines, azides, ethers, sulfides, and nitriles. The value of the method was demonstrated in straightforward syntheses of the drugs rac-Clopidogrel and S-Fendiline.

Solution photochemistry of [ p -(Dimethylamino)phenyl]pentazole (DMAPP) at 193 and 300 nm

The photochemistry of [p-(dimethylamino)phenyl]pentazole (DMAPP) at 193 nm and in the near UV is reported, with emphasis on the nature of the final stable products. The (dimethylamino)phenyl azide (DMAPA) is found as a major product in MeCN, but not in dichloromethane (DCM). (In this paper the acronyms DMAPP and DMAPA refer to the para isomers.) The photochemistry of DMAPA is also explored for comparison. The data obtained in MeCN solutions are consistent with the initial formation of the corresponding nitrene, but in DCM, different products are found, on the basis of NMR data. In the case of high reactant concentration in DCM (10-2 M), quantitative conversion of DMAPP and DMAPA is observed, indicating a high quantum yield. In contrast, MeCN solutions react much more slowly. A radical-type chain reaction mechanism is proposed to account for this observation. At high dilution, DMAPP is completely converted to products in both solvents. Possible mechanisms accounting for these results are discussed.

Halogenation of benzyl- and (heteroaromatic methyl)cobaloximes: Direct competition between ring halogenation and cobalt-carbon bond cleavage

(4-Acetamidobenzyl)- and (4-(dimethylamino)benzyl)cobaloximes react rapidly with low concentrations of chlorine and bromine in acetic acid or chloroform at room temperature under nitrogen. Both ring-halogenated organometallic products and direct Co-C cleavage products are formed. However, (4-methoxybenzyl)cobaloxime forms 4-methoxy-2-halotoluene as the exclusive product. (3-Methylbenzyl)cobaloxime undergoes a substantial proportion of ring substitution by both Br2 and Cl2 in competition with the cleavage of the Co-C bond. (3-Methoxybenzyl)cobaloxime forms only the ring-substituted organometallic product. A remarkable difference in reactivity between 2- and 3-isomers of the (thienylmethyl)- and (furylmethyl)cobaloximes is observed; for example, Co-C cleavage is the primary process in furfuryl- and (2-thienylmethyl)cobaloximes whereas ring halogenation occurs much faster in the 3-isomer. The results are discussed in terms of a σ-π delocalization phenomenon by which the electronic effect of a substituent in the benzyl group is effectively transmitted to the Co-C bond reactivity. The substituent effect of the metallomethyl group -CH2Co(dmgH)2py is found to be more than that of the methoxy group. The mechanism of the Co-C cleavage is described.

Halogenolysis of Benzylcobaloximes

The reaction of substituted benzylcobaloximes p-RC6H4Co(dmgH)2-Py (R=OMe, NHCOCH3 and NMe2) and m-RC6H4CH2Co(dmgH)2Py (R=Me, OMe) with halogens (Cl2 and Br2) in chloroform under nitrogen forms ring substituted organic and organometallic products.