42607-21-6

Basic information

• Product Name: 2-PHENYL-1,3-THIAZOLANE-4-CARBOXYLIC ACID
• Synonyms: 2-phenyl-4-thiazolidinecarboxylicaci;2-phenyl-4-thiazolidinecarboxylicacid;4-carboxy-2-phenylthiazolidine;2-PHENYL-THIAZOLIDINE-4-CARBOXYLIC ACID;2-PHENYL-1,3-THIAZOLANE-4-CARBOXYLIC ACID;2-PHENYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID;R-2-PHENYL-THIAZOLIDINE-4-CARBOXYLIC ACID;(4R)-2-Phenylthiazolidine-4-carboxylic acid
• CAS NO: 42607-21-6
• Molecular Formula: C₁₀H₁₁NO₂S
• Molecular Weight: 209.26
• Mol File: 42607-21-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 178-179°C
• Boiling Point: 433.6±45.0 °C(Predicted)
• Appearance: White/Solid
• Density: 1.2418 (rough estimate)
• Refractive Index: 1.6800 (estimate)
• PKA: 1.98±0.40(Predicted)
• Water Solubility: 941.7mg/L(21 oC)
• CAS DataBase Reference: 2-PHENYL-1,3-THIAZOLANE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-1,3-THIAZOLANE-4-CARBOXYLIC ACID(42607-21-6)
• EPA Substance Registry System: 2-PHENYL-1,3-THIAZOLANE-4-CARBOXYLIC ACID(42607-21-6)

Safety Data

• Hazard Codes: Xi
• RTECS: XJ5426700
• HazardClass: IRRITANT
• Hazardous Substances Data: 42607-21-6(Hazardous Substances Data)

Usage

General Description

2-PHENYL-1,3-THIAZOLANE-4-CARBOXYLIC ACID, also known as thiazolidine-4-carboxylic acid, is a heterocyclic compound that contains a five-membered thiazolidine ring with a phenyl group attached at the 2-position and a carboxylic acid moiety at the 4-position. It is a colorless, crystalline solid with a faint odor. 2-PHENYL-1,3-THIAZOLANE-4-CARBOXYLIC ACID has been studied for its potential pharmacological applications, including its anti-inflammatory and anti-oxidative properties. It has also been investigated for its role in the synthesis of various pharmaceutical and agrochemical intermediates. Additionally, it has shown potential in the treatment of various diseases, such as diabetes and Alzheimer's. Overall, 2-PHENYL-1,3-THIAZOLANE-4-CARBOXYLIC ACID is a versatile compound with potential applications in various fields, including medicine and agriculture.

InChI:InChI=1/C10H17NO2S/c12-10(13)8-6-14-9(11-8)7-4-2-1-3-5-7/h7-9,11H,1-6H2,(H,12,13)/t8-,9?/m1/s1

Upstream product

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Downstream Products

• 131570-67-7 (1R,3aS,4aR,7aR)-1-Phenyl-4a-((E)-propenyl)-hexahydro-cyclopenta[d]thiazolo[4,3-b]oxazole 
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• 131570-73-5 (1R,3R,6S,7S,11S)-3,11-Diphenyl-4-thia-2-aza-tricyclo[5.3.1.0^2,6]undecan-8-one 
• 131570-66-6 (1S,3aR,4aS,7aS)-1-Phenyl-4a-((E)-styryl)-hexahydro-cyclopenta[d]thiazolo[4,3-b]oxazole 
• 131570-74-6 (3R,4aR,7aR,8R,8aS)-3-Phenyl-8-((E)-styryl)-hexahydro-cyclopenta[4,5]pyrrolo[1,2-c]thiazol-7-one 
• 131570-75-7 (1R,3R,6S,7S,11R)-3-Phenyl-11-((E)-styryl)-4-thia-2-aza-tricyclo[5.3.1.0^2,6]undecan-8-one 
• 852835-12-2 C₁₇H₁₄N₂O₅S 
• 1207272-67-0 (R)-3-phenyl-7-trifluoromethyl-1H,3H-pyrrolo[1,2-c]thiazole 
• 1207272-63-6 C₁₄H₁₂F₃NO₃S 
• 83267-89-4 C₅H₅FeC₅H₄CH₂(C₃H₄NS(COOH)(C₆H₅)) 
• 100-53-8 phenylmethanethiol 

Relevant articles and documents

S-aroylthiooximes: A facile route to hydrogen sulfide releasing compounds with structure-dependent release kinetics

We report the facile preparation of a family of S-aroylthiooxime (SATO) H2S donors, which are synthesized via a click reaction analogous to oxime formation between S-aroylthiohydroxylamines (SATHAs) and aldehydes or ketones. Analysis of cysteine-triggered H2S release revealed structure-dependent release kinetics with half-lives from 8-82 min by substitution of the SATHA ring. The pseudo-first-order rate constants of substituted SATOs fit standard linear free energy relationships (p = 1.05), demonstrating a significant sensitivity to electronic effects.

THE METHOD OF SYNTHESIZING ERGOTHIONEINE AND ANALOGS

The present disclosure relates to a method for synthesizing ergothioneine or one of the derivatives thereof of following formula (I): or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in all proportions thereof, from a compound of betaine type of following formula (II): or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in all proportions thereof, by cleavage reaction in the presence of a thiol, at a temperature above or equal to 60° C. The present disclosure also relates to compounds of formula (II) and the method of synthesis thereof.

REACTIVITY OF TRIMETHYLSILYLATED DERIVATIVES OF CYSTEINE AND 2-MERCAPTOETHYLAMINE RELATIVE TO AROMATIC ALDEHYDES

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