42729-95-3

Usage

Uses

Used in Pharmaceutical Industry:
1,4-Butanediol, monomethanesulfonate is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly for the production of busulfan, an alkylating agent with antileukemic activity. Its role in the synthesis process is crucial for the development of drugs that target and treat leukemia.
Used in Cancer Treatment:
1,4-Butanediol, monomethanesulfonate is used as a precursor for the production of busulfan, which is an effective antileukemic agent. Busulfan is employed in the treatment of various types of leukemia, including chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML). 1,4-Butanediol, monomethanesulfonate's alkylating properties enable it to interfere with the DNA replication process in cancer cells, ultimately leading to cell death and tumor regression.
Used in Research and Development:
1,4-Butanediol, monomethanesulfonate is also utilized in research and development for the study of its chemical properties and potential applications in various fields. Its unique structure and reactivity make it an interesting compound for further investigation and potential development of new drugs and materials.

InChI:InChI=1/C5H12O4S/c1-10(7,8)9-5-3-2-4-6/h6H,2-5H2,1H3

Upstream product

• 121683-04-3 4-(benzyloxy)butyl methanesulfonate 
• 110-63-4 Butane-1,4-diol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 14970-83-3 4-Mercapto-1-butanol 

Relevant academic research and scientific papers

Application of Cp2TiCl-Promoted Radical-Induced Cyclization: An Expeditious Access to [ a]-Annelated Indoles

An efficient and novel route for assembling pyrrolo/piperido[1,2-a]indoles is portrayed involving a radical-mediated reductive epoxide opening reaction of N-tethered epoxy-indoles that trigger facile intramolecular cyclization followed by an oxidative quenching step. Capitalizing on the operational simplicity of the method involving just two steps and use of an efficient C-C bond-forming reaction, this radical-based protocol enables the modular assembly of an important class of N-fused indole derivatives with versatile functional and structural diversity.

A 4 - mercapto -1 - butanol synthesis process

The present invention discloses a 4-mercapto-1-butanol synthesis process, which comprises: 1) dissolving 1,4-butanediol and an acid-binding agent in an organic solvent I, adding a sulfonylation agent in a dropwise manner to carry out a sulfonylation reaction, carrying out extraction separation with dichloromethane, and carrying out washing, drying and concentration to obtain a colorless oil-like substance; and 2) dissolving the colorless oil-like substance obtained in the step 1) in an organic solvent II, adding a nucleophile to carry out a nucleophilic substitution reaction, and finally carrying out pressure reducing distillation to obtain the 4-mercapto-1-butanol. According to the present invention, the completely-new 4-mercapto-1-butanol synthesis route is provided, the used raw materials are easy to obtain, the operation is simple, the reaction conditions are not harsh, and good industrial values are provided.

Enantiopure sulforaphane analogues with various substituents at the sulfinyl sulfur: Asymmetric synthesis and biological activities

(Chemical Equation Presented) A convergent and high-yielding approach for the asymmetric synthesis of sulforaphane 2 and four analogues differently substituted at the sulfinyl sulfur has been developed. The key step of the synthesis is the diastereoselect