42731-71-5

Upstream product

• 100-46-9 benzylamine 
• 106350-09-8 2,6-dibenzyl-2,3,5,6-tetrahydro-4-hydroximino-3,5-dioxo-1,2,6-thiadiazine 1,1-dioxide 
• 78-81-9 isobutylamine 
• 107-85-7 1-amino-3-methylbutane 
• 75-64-9 tert-butylamine 
• 74282-81-8 2-hydroxyphenyl N-benzylsulfamate 
• 16475-29-9 phenylchlorosulfate 

Downstream Products

• 25829-06-5 Bis(benzylidenamino)disulfid 
• 25829-04-3 N,N'-dibenzylidene-tetrasulfanediamine 
• 31264-00-3 Bis(benzylidenamino)sulfid 
• 102276-42-6 N,1-Bis-(phenylmethyl)-hydrazinsulfonamid 
• 102276-35-7 N,1-Bis-(phenylmethyl)-2-(phenylmethylen)-hydrazinsulfonamid 
• 1257228-91-3 C₂₆H₂₆N₂O₄S 
• 1615-08-3 1,3-dibenzyl-1H,3H-2,1,3-benzothiadiazole 2,2-dioxide 
• 106350-05-4 2,6-dibenzyl-(2,3,5,6-tetrahydro)-1,2,6-thiadiazin-3,5-dione 1,1-dioxide 

Relevant academic research and scientific papers

Conventional and microwave-assisted solvent-free synthesis of fused [1,2,5]thiadiazolo[3,4-b]quinoxaline-2,2-dioxide derivatives

A simple, highly efficient and environmentally friendly procedure for the condensation of ο$-phenylenediamine with 2,5-dialkyl-1,2,5- thiadiazolidine-3,4-dione-1,1-dioxides via two microwave-assisted reactions is described. These compounds were also prepared via a conventional heating method to provide a comparison with the microwave-assisted irradiation reaction protocol. The structures of the synthesized compounds were confirmed using infrared, 1H NMR and mass spectral analysis.

The Zeolite ZSM-5-SO3H as an Effcient Mild Heterogeneous Catalyst for the Synthesis of 1,2,5-Thiadiazolidines, 1,2,6-Thiadiazines, and Benzo[d][1,2,7] thiadiazepines Under Microwave-assisted Solvent-free Conditions

Three series of compounds namely,1,2,5-thiadiazolidine-3,4(H)-dione-1,1-dioxydes, 1,2,6-thiadiazine-3,5(H)-dione-1,1-dioxydes, and benzo[d][1,2,7]thiadiazepine-1,5(2H)-dione-3,3-dioxydes have been synthesized by the acylation of N,N’-disubstituted symmetric sulfamides with oxalyl chloride, malonyl chloride, and phthaloyl chloride, respectively. These compounds were prepared under conventional and microwave-assisted solvent-free reaction conditions using the zeolite ZSM-5-SO3H as catalyst.

Ultrasonic assisted green protocol for the synthesis of sulfamides

An improved environmentally benign method for synthesis of sulfamides under focused ultrasound irradiation and under solvent-free and catalyst-free conditions has been carried out by the reaction of amines or amino esters with sulfuryl chloride. This approach allows the synthesis of products in excellent yields and in short reaction time.

Vicinal Diamination of Arenes with Domino Aryne Precursors

Vicinal diamination of domino aryne precursors was achieved with sulfamides. The reaction proceeds through a two-aryne pathway, accepting two N-nucleophiles at the 1,2-positions of an arene ring. Symmetrical and unsymmetrical diaminobenzenes were readily obtained.

Antibacterial activity and global reactivity descriptors of some newly synthesized unsymmetrical sulfamides

In the present study a series of unsymmetric linear sulfamides (1-9) starting from a primary amine were synthesized and their structures were confirmed by elemental analyses, mass spectrometry and1 H NMR techniques. All the synthesized compounds were scre

Microwave-assisted synthesis of some substituted sulfamides

Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by amine-exchange reaction, was studied in a modified domestic microwave oven. Reaction times and yields under microwave radiation were compared with classical heating. Synthesis of the sulfamides under microwave irradiation gave better yields with the desired compounds, and in considerably reduced reaction times, than those obtained by classical heating. [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures.]

Hypervalent iodine reagent mediated diamination of [60]fullerene with sulfamides or phosphoryl diamides

A hypervalent iodine-promoted intermolecular diamination reactions of C60 with sulfamides or phosphoryl diamides affords two classes of novel C60-fused cyclic sulfamide or phosphoryl diamide derivatives. The reaction between C60 and sulfamides can be effectively controlled to selectively synthesize diamination products or azafulleroids under PhIO/I2 or PhI(OAc)2/I2 conditions, respectively. Moreover, phosphoryl diamides were first used as an amine source in the diamination of alkenes.

Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV

A set of sulfamides and sulfamates were synthesized and tested against several isoforms of carbonic anhydrase: CA I, CA II, CA VII, CA XII and CA XIV. The biological assays showed a broad range of inhibitory activity, and interesting results were found for several compounds in terms of activity (Ki 1 μm) and selectivity: some aromatic sulfamides are active against CA I, CA II and/or CA VII; while they are less active in CA XII and CA XIV. On the other hand, bulky sulfamides are selective to CA VII. To understand the origin of the different inhibitory activity against each isozyme we used molecular modeling techniques such as docking and molecular dynamic simulations.

3D-QSAR design of novel antiepileptic sulfamides

A three-dimensional quantitative structure-activity relationship method, the comparative molecular field analysis (CoMFA), was applied to design new anticonvulsant symmetric sulfamides. The training set (27 structures) was comprised by traditional and new-generation anticonvulsant (AC) ligands that exhibit a potent activity in MES test. Physicochemical determinants of binding, such as steric and electrostatic properties, were mapped onto the molecular structures of the set, in order to interpret graphically the CoMFA results in terms of field contribution maps. The 3D-QSAR models demonstrate a good ability to predict the activity of the designed compounds (r2 = 0.967, q2 = 0.756).