42748-07-2

Basic information

• Product Name: 4H-Thieno[3,2-b]pyrrole-2-carboxylic acid, 5-phenyl-, methyl ester
• CAS NO: 42748-07-2
• Molecular Formula: C14H11NO2S
• Molecular Weight: 257.313
• Mol File: 42748-07-2.mol

Chemical Properties

• CAS DataBase Reference: 4H-Thieno[3,2-b]pyrrole-2-carboxylic acid, 5-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Thieno[3,2-b]pyrrole-2-carboxylic acid, 5-phenyl-, methyl ester(42748-07-2)
• EPA Substance Registry System: 4H-Thieno[3,2-b]pyrrole-2-carboxylic acid, 5-phenyl-, methyl ester(42748-07-2)

Safety Data

• Hazardous Substances Data: 42748-07-2(Hazardous Substances Data)

Upstream product

• 42747-98-8 4-nitro-5-trans-styryl-thiophene-2-carboxylic acid methyl ester 
• 858848-58-5 methyl 4-nitro-5-(2-phenylethenyl)thiophene-2-carboxylate 
• 56921-01-8 5-methyl-4-nitro-thiophene-2-carboxylic acid methyl ester 
• 100-52-7 benzaldehyde 

Downstream Products

• 848243-48-1 methyl 4-(2-tert-butoxy-2-oxoethyl)-6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylate 
• 848243-49-2 [6-cyclohexyl-2-(methoxycarbonyl)-5-phenyl-4H-thieno[3,2-b]pyrrol-4-yl]acetic acid 

Relevant articles and documents

Palladium-catalyzed reductive N-heterocyclization of alkenyl-substituted nitroarenes as a viable method for the preparation of bicyclic pyrrolo-fused heteroaromatic compounds

Palladium-catalyzed, carbon monoxide-mediated reductive N-heterocyclization of nitro-heteroaromatic compounds having an alkene adjacent to the nitro-group affords bicyclic pyrrolo-fused heteroaromatic molecules. This type of reaction was used to prepare the fused bicyclo[3.3.0] ring-system: thieno[3,2-b]pyrrole, thieno[2,3-b]pyrrole, furo[2,3-b]pyrrole, pyrrolo[3,2-d]thiazole, and pyrrolo[2,3-d]imidazole and the bicyclo[4.3.0] ring-systems: pyrrolo[3,2-b]pyridine, pyrrolo[2,3-b]pyridine, pyrrolo[3,2-c]pyridine, pyrrolo[2,3-c]pyridine, pyrrolo[3,2-c]pyridazine, and pyrrolo[3,2-d]pyrimidine in 32-94% yield.

Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase

Thieno[3,2-b]pyrroles are a novel class of allosteric inhibitors of HCV NS5B RNA-dependent RNA polymerase which show potent affinity for the NS5B enzyme. Introduction of a polar substituent in the position N1 led to a compound that efficiently blocks subg

THIENOPYRROLES AS ANTIVIRAL AGENTS

The present invention relates to thienopyrrole compounds of formula (I); wherein A, B, Y, Ar, n, Z and X1 are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.