858848-58-5Relevant academic research and scientific papers
Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase
Ontoria, Jesus M.,Martin Hernando, Jose I.,Malancona, Savina,Attenni, Barbara,Stansfield, Ian,Conte, Immacolata,Ercolani, Caterina,Habermann, Joerg,Ponzi, Simona,Di Filippo, Marcello,Koch, Uwe,Rowley, Michael,Narjes, Frank
, p. 4026 - 4030 (2006)
Thieno[3,2-b]pyrroles are a novel class of allosteric inhibitors of HCV NS5B RNA-dependent RNA polymerase which show potent affinity for the NS5B enzyme. Introduction of a polar substituent in the position N1 led to a compound that efficiently blocks subg
