848243-49-2

Upstream product

• 56921-01-8 5-methyl-4-nitro-thiophene-2-carboxylic acid methyl ester 
• 42748-07-2 5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester 
• 100-52-7 benzaldehyde 
• 848243-46-9 methyl 6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylate 
• 858848-58-5 methyl 4-nitro-5-(2-phenylethenyl)thiophene-2-carboxylate 
• 848243-48-1 methyl 4-(2-tert-butoxy-2-oxoethyl)-6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylate 

Relevant academic research and scientific papers

Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase

Thieno[3,2-b]pyrroles are a novel class of allosteric inhibitors of HCV NS5B RNA-dependent RNA polymerase which show potent affinity for the NS5B enzyme. Introduction of a polar substituent in the position N1 led to a compound that efficiently blocks subg

THIENOPYRROLES AS ANTIVIRAL AGENTS

The present invention relates to thienopyrrole compounds of formula (I); wherein A, B, Y, Ar, n, Z and X1 are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.