35657-36-4

Basic information

• Product Name: O-(4-nitrobenzoyl)hydroxylamine
• Synonyms: O-(4-nitrobenzoyl)hydroxylamine;NbzONH2;O-(4-Nitrobenzoyl)hydroxylaMine 98%, >=97.5% (HPLC);amino 4-nitrobenzoate;O-(4-Nitrobenzoyl)hydroxylamine;O-(4-Nitrobenzoyl);O-(4-Nitrobenzoyl)hydroxylamine≥ 98%(HPLC);Benzoic acid, 4-nitro-, azanyl ester
• CAS NO: 35657-36-4
• Molecular Formula: C₇H₆N₂O₄
• Molecular Weight: 182.13354
• Product Categories: Building Blocks;Chemical Synthesis;Hydroxylamines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 35657-36-4.mol

Chemical Properties

• Melting Point: 85.0℃ (decomposition)
• Boiling Point: 361.4±44.0 °C(Predicted)
• Appearance: /
• Density: 1.441±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -2.68±0.70(Predicted)
• BRN: 1966666
• CAS DataBase Reference: O-(4-nitrobenzoyl)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(4-nitrobenzoyl)hydroxylamine(35657-36-4)
• EPA Substance Registry System: O-(4-nitrobenzoyl)hydroxylamine(35657-36-4)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 35657-36-4(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow powder

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 75-75-2 methanesulfonic acid 
• 35657-41-1 tert-butyl [(4-nitrobenzoyl)oxy]carbamate. 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 1085941-27-0 O-(4-nitrobenzoyl)hydroxylamine methanesulfonic acid salt 

Downstream Products

• 427878-69-1 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 306732-27-4 (E)-4-chlorobenzaldehyde O-(4-nitrobenzoyl)oxime 
• 16062-00-3 (E)-4-methoxybenzaldehyde O-(4-nitrobenzoyl) oxime 
• 1445656-87-0 1,2-diamino-3-methoxypyridinium 4-nitrobenzoate 
• 1312580-87-2 4-{1-amino-4-chloro-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-N-(1-methyl-piperidin-4-yl)-benzamide 

Relevant articles and documents

Photo-auxiliary approach to control excited state reactivity: Cross [2+2]-photocycloaddition of oxazolidinone based hydrazides

Chiral oxazolidinone based hydrazides undergo efficient cross [2 + 2]-photocycloaddition upon visible light illumination. Oxazolidinone functionality acted as an energy harvesting photo-auxiliary. The cross [2 + 2]-photocycloaddition proceeded efficiently from the excited state with moderate to excellent isolated yield of the photoproduct. The photo-auxiliary can be conveniently removed post-photoreaction, which highlights the versatility of this strategy.

Development of a practical synthesis of a p38 kinase inhibitor via a safe and robust amination

The development of a practical synthesis for a p38 kinase inhibitor is described. The key advances include an improved route to the key intermediate, a substituted pyrrole, and a subsequent animation utilizing O-(4-nitrobenzoyl)- hydroxylamine, which provides a safe, scalable, and robust amination method. The new protocol was successfully demonstrated to generate 1.6 kg of API in seven steps and 26% overall yield.

Fischer synthesis of isomeric thienopyrrole LHRH antagonists

As part of a structure-activity exploration into LHRH antagonists, structures containing the thieno[2,3-b]pyrrole core were identified as potent antagonists. This letter describes the employment of the Fischer synthesis to access this thienopyrrole and isomeric final compounds.

KINESIN INHIBITORS

This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat a kinesin Eg5 protein-mediated disorder.

Amination of heterocyclic compounds with O-benzoylhydroxylamine derivatives

The N-amination of heterocyclic compounds 1a - k with O- benzoylhydroxylamine derivatives 5 was developed and demonstrated to be a superior alternative to existing N-amination methods. A structure - reactivity relationship study was performed on variously

Method for preparing pyrrolotriazine compounds

A method for aminating pyrrole derivatives and for preparing pyrrolotriazine compounds having the formula V,