42832-42-8

Basic information

• Product Name: N-(prop-2-en-1-yloxy)acetamide
• CAS NO: 42832-42-8
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.1305
• Mol File: 42832-42-8.mol
• Article Data: 5

Chemical Properties

• Density: 0.971g/cm³
• Refractive Index: 1.425
• CAS DataBase Reference: N-(prop-2-en-1-yloxy)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(prop-2-en-1-yloxy)acetamide(42832-42-8)
• EPA Substance Registry System: N-(prop-2-en-1-yloxy)acetamide(42832-42-8)

Safety Data

• Hazardous Substances Data: 42832-42-8(Hazardous Substances Data)

Upstream product

• 38945-21-0 O-allylhydroxylamine hydrochloride 
• 108-24-7 acetic anhydride 
• 546-88-3 acetylhydroxamic acid 
• 106-95-6 allyl bromide 
• 6542-54-7 O-Allylhydroxylamine 
• 64-19-7 acetic acid 
• 141-78-6 ethyl acetate 
• 107-05-1 3-chloroprop-1-ene 

Downstream Products

• 38945-21-0 O-allylhydroxylamine hydrochloride 
• 6542-54-7 O-Allylhydroxylamine 
• 4284-54-2 1-Acetyl-1-allyloxy-3--harnstoff 

Relevant articles and documents

Novel fluorinated 7-hydroxycoumarin derivatives containing an oxime ether moiety: Design, synthesis, crystal structure and biological evaluation

A series of fluorinated 7-hydroxycoumarin derivatives containing an oxime ether moiety have been designed, synthesized and evaluated for their antifungal activity. All the target compounds were determined by1H-NMR,13C-NMR, FTIR and HR-MS spectra. The single-crystal structures of compounds 4e, 4h, 5h and 6c were further confirmed using X-ray diffraction. The antifungal activities against Botrytis cinerea (B. cinerea), Alternaria solani (A. solani), Gibberella zeae (G. zeae), Rhizoctorzia solani (R. solani), Colletotrichum orbiculare (C. orbiculare) and Alternaria alternata (A. alternata) were evaluated in vitro. The preliminary bioassays showed that some of the designed compounds displayed the promising antifungal activities against the above tested fungi. Strikingly, the target compounds 5f and 6h exhibited outstanding antifungal activity against B. cinerea at 100 μg/mL, with the corresponding inhibition rates reached 90.1 and 85.0%, which were better than the positive control Osthole (83.6%) and Azoxystrobin (46.5%). The compound 5f was identified as the promising fungicide candidate against B. cinerea with the EC50 values of 5.75 μg/mL, which was obviously better than Osthole (33.20 μg/mL) and Azoxystrobin (64.95 μg/mL). Meanwhile, the compound 5f showed remarkable antifungal activities against R. solani with the EC50 values of 28.96 μg/mL, which was better than Osthole (67.18 μg/mL) and equivalent to Azoxystrobin (21.34 μg/mL). The results provide a significant foundation for the search of novel fluorinated 7-hydroxycoumarin derivatives with good antifungal activity.

Synthesis of N-Pyridyl Hydroxylamines via Copper-Catalyzed Cross-Coupling

N -Pyridyl hydroxylamine derivatives were prepared via copper-catalyzed cross-coupling of orthogonally functionalized hydroxylamines with iodopyridines. Various amino- and hydroxyl-protecting groups were tolerated. A total of 20 examples were synthesized in 28-90percent yield.

Identification and evaluation of O-alkyl substituted hydroxamic acids as potent in vitro inhibitors of the hepatic glycine cleavage system and investigation of their action on in vivo central nervous system glycine concentration

The identification and evaluation of an extensive series of O-alkyl substituted hydroxamic acids as potent in vitro inhibitors of the hepatic glycine cleavage system is described. An investigation of the action of selected examples on the in vitro brain glycine cleavage system and their influence on in vivo plasma and central nervous system glycine concentrations following systemic administration is also reported.