428509-73-3Relevant academic research and scientific papers
A strategy for the stereoselective synthesis of unsymmetric atropisomeric ligands: Preparation of NAPhePHOS, a new biaryl diphosphine
Michaud, Guillaume,Bulliard, Michel,Ricard, Louis,Genet, Jean-Pierre,Marinetti, Angela
, p. 3327 - 3330 (2002)
MeO-NAPhePHOS represents the first example of a new series of atropisomeric diphosphines bearing heterotopic biaryl moieties. The key step of its synthesis is the diastereoselective, intramolecular, Cu1-promoted coupling of 1-iodonaphthol and 2-iodo-3-methoxyphenol connected by a chiral tether. (R,R)-2,4-Pentanediol is used as the chiral auxiliary in this highly selective reaction that leads to a single enantiomer of the title diphosphine. In the Ru-promoted hydrogenations of carbonyl derivatives, NAPhePHOS affords enantioselectivity enantioselectivity levels fully comparable to those of the C2-symmetrical analogues, BINAP and MeO-BIPHEP respectively, thus showing that the lack of C2 symmetry is not detrimental to the catalytic properties of atropisomeric ligands in these hydrogenation reactions.
The metal complex and homochiral diphosphines
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Page 22-23, (2010/02/11)
Novel chiral diphosphines (R) or (S), and their use as optically active ligand for preparing diphosphino-metallic complexes, and the diphosphino-metallic complexes containing said chiral diphosphines (R) or (S), and the use of the diphosphino-metallic com
