428861-10-3

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 428861-09-0 6-methoxy-5,6-benzo-2,2'-biphenol 
• 428509-73-3 (2R,4R)-4-(α-iodo-β-naphthyloxy)-2-(2''-iodo-3''-methoxyphenyloxy)pentane 
• 428509-74-4 (2S,4R)-4-(α-iodo-β-naphthyloxy)-2-pentanol 
• 2033-42-3 1-iodo-2-hydroxynaphthalene 

Relevant academic research and scientific papers

The metal complex and homochiral diphosphines

Novel chiral diphosphines (R) or (S), and their use as optically active ligand for preparing diphosphino-metallic complexes, and the diphosphino-metallic complexes containing said chiral diphosphines (R) or (S), and the use of the diphosphino-metallic com

A strategy for the stereoselective synthesis of unsymmetric atropisomeric ligands: Preparation of NAPhePHOS, a new biaryl diphosphine

MeO-NAPhePHOS represents the first example of a new series of atropisomeric diphosphines bearing heterotopic biaryl moieties. The key step of its synthesis is the diastereoselective, intramolecular, Cu1-promoted coupling of 1-iodonaphthol and 2-iodo-3-methoxyphenol connected by a chiral tether. (R,R)-2,4-Pentanediol is used as the chiral auxiliary in this highly selective reaction that leads to a single enantiomer of the title diphosphine. In the Ru-promoted hydrogenations of carbonyl derivatives, NAPhePHOS affords enantioselectivity enantioselectivity levels fully comparable to those of the C2-symmetrical analogues, BINAP and MeO-BIPHEP respectively, thus showing that the lack of C2 symmetry is not detrimental to the catalytic properties of atropisomeric ligands in these hydrogenation reactions.