42866-92-2

Basic information

• Product Name: Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-
• Synonyms: Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-;4-Methoxyphenylacetaldehyde diMethylacetal;1-(2,2-DiMethoxyethyl)-4-Methoxybenzene
• CAS NO: 42866-92-2
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.24
• Mol File: 42866-92-2.mol
• Article Data: 6

Chemical Properties

• Flash Point: >110℃
• Appearance: /
• Density: 1.032 g/mL at 25 °C
• Refractive Index: n20/D1.504
• CAS DataBase Reference: Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-(42866-92-2)
• EPA Substance Registry System: Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-(42866-92-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 42866-92-2(Hazardous Substances Data)

Usage

General Description

Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-, also known as veratrole, is a chemical compound with the formula C11H16O3. It is a colorless liquid with a distinct aromatic odor, often used as a fragrance ingredient or flavoring agent. Veratrole is used in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also employed as a solvent in organic reactions and as a stabilizer in some types of polymers. Veratrole is considered to have low toxicity, but certain precautions should be taken when handling it, as it may irritate the skin, eyes, and respiratory system.

Upstream product

• 67-56-1 methanol 
• 637-69-4 4-Methoxystyrene 
• 546-67-8 lead(IV) tetraacetate 
• 824-94-2 p-methoxybenzyl chloride 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 149-73-5 trimethyl orthoformate 
• 20401-88-1 3-(4-methoxyphenyl)propional 
• 74447-45-3 2-(4-methoxyphenyl)methyl-1,3-dithiane 

Downstream Products

• 74447-44-2 1-azido-2-(4-methoxyphenyl)ethane 
• 5107-52-8 2-(p-methoxyphenyl)ethyl toluene-p-sulphonate 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 145744-17-8 (E)-N-carbethoxy-N-(4'-methoxystyryl)-2-(2'-bromo-4',5'-dimethoxyphenyl)ethylamine 

Relevant articles and documents

Lewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents

1,2-Diols are extremely useful building blocks in organic synthesis. Hypervalent iodine reagents are useful for the vicinal dihydroxylation of olefins to give 1,2-diols under metal-free conditions, but strongly acidic promoters are often required. Herein, we report a catalytic vicinal dioxygenation of olefins with hypervalent iodine reagents using Lewis bases as catalysts. The conditions are mild and compatible with various functional groups.

Highly Selective One-Pot Synthesis of Polysubstituted Isoflavanes using Styryl Ethers and Electron-Withdrawing ortho -Quinone Methides Generated in Situ

A highly selective one-pot synthesis of polysubstituted isoflavanes has been developed. The reaction proceeds through the cycloaddition of methyl styryl ethers, derived from phenylacetaldehyde dimethyl acetals under acidic conditions, with electron-withdrawing ortho -quinone methides generated in situ. When phenylacetaldehyde dimethyl acetals were reacted with salicylaldehydes, the reaction proceeded smoothly to afford the corresponding isoflavanes stereoselectively in high yields and with excellent regioselectivities. The present reaction provides versatile access to functionalized isoflavanes, and constitutes a useful tool for the synthesis of biologically active molecules.

A generalized approach for iron catalyzed chemo- and regioselective formation of anti-Markovnikov acetals from styrene derivatives

Fe(BF4)2·6H2O in the presence of pyridine-2,6-dicarboxylic acid and PhI(OAc)2 can efficiently catalyze the formation of chemoselective dialkyl acetals from styrene derivatives with anti-Markovnikov regioselectivity in good to high yields under mild and benign reaction conditions.