Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-

Base Information

• Chemical Name: Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-
• CAS No.: 42866-92-2
• Molecular Formula: C11H16 O3
• Molecular Weight: 196.246
• Hs Code.: 2911000000
• Mol file: 42866-92-2.mol

Synonyms:Acetaldehyde,(p-methoxyphenyl)-, dimethyl acetal (6CI,7CI); 4-(Methoxyphenyl)acetaldehydedimethyl acetal

Chemical Property of Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-

Chemical Property:

• Refractive Index: n20/D1.504
• Flash Point: >110℃
• PSA: 27.69000
• Density: 1.032 g/mL at 25 °C
• LogP: 1.85660

Purity/Quality:

97% ^*data from raw suppliers

4-Methoxyphenylacetaldehyde dimethylacetal 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy-

There total 8 articles about Benzene, 1-(2,2-dimethoxyethyl)-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 4-Methoxystyrene (637-69-4,24936-44-5) → 2-(4-methoxyphenyl)acetaldehyde dimethyl acetal (42866-92-2)

Guidance literature:

With Pyridine-2,6-dicarboxylic acid; iron(II) tetrafluoroborate hexahydrate; [bis(acetoxy)iodo]benzene; at 20 ℃; for 20h; regioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1039/c2cc17889c

Reference yield:

4-Methoxyphenylacetaldehyde (5703-26-4) + trimethyl orthoformate (149-73-5) → 2-(4-methoxyphenyl)acetaldehyde dimethyl acetal (42866-92-2)

Guidance literature:

With magnesium sulfate; toluene-4-sulfonic acid; In methanol; dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.tet.2019.130883

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 2-(4-methoxyphenyl)acetaldehyde dimethyl acetal (42866-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 9.1 g / n-butyl-lithium / tetrahydrofuran; hexane / 1.) -78 --> -23 deg C, 1.5 h, 2.) 0 deg C, 14 h

2: 1.18 g / ceric ammonium nitrate / acetonitrile / 0.05 h / Ambient temperature

With n-butyllithium; ammonium cerium(IV) nitrate; In tetrahydrofuran; hexane; acetonitrile;

upstream raw materials:

methanol

4-Methoxystyrene

lead(IV) tetraacetate

2-(4-methoxyphenyl)methyl-1,3-dithiane

Downstream raw materials:

1-azido-2-(4-methoxyphenyl)ethane

2-(p-methoxyphenyl)ethyl toluene-p-sulphonate

2-(4-Methoxyphenyl)ethanol

4-Methoxyphenylacetaldehyde