42867-74-3

Usage

Uses

Used in Pharmaceutical Industry:
Uridine, 2',3'-didehydro-2',3'-dideoxy-, 5'-acetate is used as a potential antiviral agent for inhibiting the replication of certain viruses. Its 2',3'-didehydro-2',3'-dideoxy modification interferes with the synthesis of viral genetic material, while the 5'-acetate group may further enhance its antiviral activity.
Used in Research Applications:
In the field of virology, Uridine, 2',3'-didehydro-2',3'-dideoxy-, 5'-acetate is used as a research tool to study the mechanisms of viral replication and inhibition. This understanding can aid in the development of more effective antiviral strategies and treatments.

Upstream product

• 108-24-7 acetic anhydride 
• 116597-18-3 1-(5-O-acetyl-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)uracil 

Downstream Products

• 15379-29-0 1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-5-fluorouracil 
• 5983-09-5 2',3'-Dideoxyuridine 
• 135080-81-8 {(2S,5R)-5-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,5-dihydro-furan-2-ylmethoxymethyl}-phosphonic acid diethyl ester 
• 135080-82-9 {(2S,5R)-5-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,5-dihydro-furan-2-ylmethoxymethyl}-phosphonic acid 
• 135080-80-7 1-((2R,5S)-5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-3-(4-methoxy-benzyl)-1H-pyrimidine-2,4-dione 
• 144989-72-0 1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-5-iodo-uracil 
• 66-22-8 uracil 
• 5974-93-6 2',3'-dideoxy-2',3'-didehydrouridine 

Relevant academic research and scientific papers

2,2′-Anhydro-1-(3′,5′-di-O-acetyl-β-d- arabinofuranosyl)uracil, a cyclouridine nucleoside with a C4′- endo furanosyl conformation

2,2′-Anhydro-1-(3′,5′-di-O-acetyl-β-d- arabinofuranosyl)uracil, C13H14N2O7, was obtained by refluxing 2′,3′-O-(methoxymethylene)uridine in acetic anhydride. The structure exhibits a nearly perfect C4′- endo (4 E) conformation. The best four-atom plane of the five-membered furanose ring is O - C - C - C, involving the C atoms of the fused five-membered oxazolidine ring, and the torsion angle is only -0.4 (2)°. The oxazolidine ring is essentially coplanar with the six-membered uracil ring [r.m.s. deviation = 0.012 (5) A and dihedral angle = -3.2 (3)°]. The conformation at the exocyclic C - C bond is gauche-trans which is stabilized by various C - H...π and C - O...π interactions. Copyright