428866-15-3

Basic information

• Product Name: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE
• Synonyms: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE
• CAS NO: 428866-15-3
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.2429
• Mol File: 428866-15-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 112 °C(Press: 7.3 Torr)
• Appearance: /
• Density: 0.984±0.06 g/cm3(Predicted)
• PKA: 3.35±0.10(Predicted)
• CAS DataBase Reference: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE(428866-15-3)
• EPA Substance Registry System: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE(428866-15-3)

Safety Data

• Hazardous Substances Data: 428866-15-3(Hazardous Substances Data)

Usage

General Description

2,2-Dimethyl-1-(5-methyl-pyridin-2-yl)-propan-1-one, also known as DMPK, is a chemical compound with the molecular formula C12H15NO. It is a ketone with a methyl substituent on the pyridine ring, and two dimethyl groups attached to the carbon chain. DMPK is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as a building block for the production of various fine chemicals. It is also employed as a reagent in chemical research and organic synthesis. Due to its versatile nature and wide range of applications, DMPK is a valuable compound in the field of organic chemistry.

Upstream product

• 3510-66-5 2-Bromo-5-methylpyridine 
• 630-18-2 tert-butyl isocyanide 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 890151-32-3 (R)-5-methyl-1-(1-(2,4,6-triisopropyl)benzyloxy-2,2-dimethylpropyl)pyridine N-oxide 
• 890151-28-7 2-[(R)-2,2-Dimethyl-1-(2,4,6-triisopropyl-benzyloxy)-propyl]-5-methyl-pyridine 
• 890151-31-2 (R)-5-methyl-1-(1-(2,4,6-trimethyl)benzyloxy-2,2-dimethylpropyl)pyridine N-oxide 
• 890151-27-6 2-[(R)-2,2-Dimethyl-1-(2,4,6-trimethyl-benzyloxy)-propyl]-5-methyl-pyridine 

Relevant articles and documents

Scandium-bipyridine-catalyzed enantioselective aminolysis of meso-epoxides

The scandium-bipyridine-catalyzed enantioselective addition of anilines and O-alkyl hydroxylamines to meso-epoxides has been optimized and extended to a broad range of epoxides and amines. Whereas aromatic meso-epoxides generally furnished the corresponding 1.2-amino alcohols in Excellent enantioselectivities, aliphatic meso-epoxides only gave rise to moderate enantioselectivities in the aminolysis. The catalyst loading may be lowered to just 5 mol% with only marginal effects on yield and enantioselectivity. A strong positive nonlinear effect has been observed, pointing to aggregation phenomena of the catalyst.

Lewis base catalyzed, enantioselective aldol addition of methyl trichlorosilyl ketene acetal to ketones

The catalytic enantioselective addition of an acetate enolate equivalent to ketones is described. Methyl trichlorosilyl ketene acetal reacts with a wide range of ketones in the presence of pyridine N-oxide to afford the aldol addition products in excellen