428874-41-3

Upstream product

• 428874-25-3 tert-butyl-(2-ethyl-pent-4-enyloxy)-diphenyl-silane 
• 253143-30-5 (R)-4-benzyl-3-((S)-2-ethylpent-4-enoyl)oxazolidin-2-one 
• 121074-21-3 (2S)-2-ethyl-4-penten-1-ol 
• 253143-31-6 4-(tert-butyl-diphenyl-silanyloxymethyl)-hexan-1-ol 

Downstream Products

• 253143-32-7 (S)-4-Benzyl-3-[(S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-hexanoyl]-oxazolidin-2-one 
• 253143-39-4 (2S,3S,6S)-2-{(4S,5R,6S)-6-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-1-methyl-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-hydroxy-6-methyl-dec-9-en-5-one 
• 253143-35-0 {(2S,4S)-4-[(4S,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-ethyl-pentyloxy}-tert-butyl-diphenyl-silane 
• 253143-34-9 (2S,4R,5S,6S,8S)-1-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxy-2,4,6-trimethyl-decan-3-one 
• 253143-36-1 (R)-2-{(4R,5R,6S)-6-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-1-methyl-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propionaldehyde 
• 382139-15-3 (5S,6S,8S,9S,10S,11S,12S,13S,15S)-15-(tert-Butyl-diphenyl-silanyloxymethyl)-10-(4-methoxy-benzyloxy)-5,9,11,13-tetramethyl-12-triethylsilanyloxy-1-trimethylsilanyl-heptadec-1-yne-6,8-diol 
• 382139-14-2 (4S,6S)-4-[(1S,2S,3S,4S,5S,7S)-7-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-1,3,5-trimethyl-4-triethylsilanyloxy-nonyl]-2,2-dimethyl-6-((S)-1-methyl-5-trimethylsilanyl-pent-4-ynyl)-[1,3]dioxane 
• 382138-93-4 (5S,8S,9S,10S,11S,12S,13S,15S)-15-(tert-Butyl-diphenyl-silanyloxymethyl)-8-hydroxy-10-(4-methoxy-benzyloxy)-5,9,11,13-tetramethyl-12-triethylsilanyloxy-1-trimethylsilanyl-heptadec-1-yn-6-one 
• 382139-17-5 2,2-Dimethyl-propionic acid (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonyl ester 
• 382139-13-1 (2S,3S,4S,5S,6S,8S)-8-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-5-triethylsilanyloxy-decan-1-ol 
• 382138-97-8 (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonanoic acid methyl ester 
• 382139-18-6 (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonanoic acid amide 
• 382138-90-1 (2S,4S,5S)-4-[(1S,2S,3S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1,3-dimethyl-2-triethylsilanyloxy-heptyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxane 
• 382138-96-7 (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonan-1-ol 

Relevant academic research and scientific papers

Enantioselective Total Synthesis of Fluvirucinin B1

A convergent synthesis of fluvirucinin B1 from acid ent-6a and nitrile ent-9, involving an organocopper coupling, a stereoselective allylation, a ring-closing metathesis reaction, and a stereoselective hydrogenation as the key steps, is reported. The starting building blocks have been prepared in a straightforward manner from a common phenylglycinol-derived lactam 1. An unprecedented regioselective oxidation of phenylglycinol-derived secondary amines 5 to carboxylic acids 6 has been developed.

A convergent three-component total synthesis of the powerful immunosuppressant (-)-sanglifehrin A

The potent immunosuppressive agent (-)-sanglifehrin A (5), initially discovered in a soil sample from Malawi, has been synthesized in a highly conver soil gent and stereocontrolled manner. The enantioselective approach relies on initial construction of th

Synthesis of the tripeptide (C1-N12) and hydroxylated hexadecene (C26-C41) domains of sanglifehrin A and C

Fully enantio-controlled routes to two major segments of the newly discovered immunosuppressants sanglifehrin A and C are described.