42917-47-5

Basic information

• Product Name: Benzene, 1-fluoro-4-[(4-methylphenyl)thio]-
• CAS NO: 42917-47-5
• Molecular Formula: C13H11FS
• Molecular Weight: 218.295
• Mol File: 42917-47-5.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzene, 1-fluoro-4-[(4-methylphenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-fluoro-4-[(4-methylphenyl)thio]-(42917-47-5)
• EPA Substance Registry System: Benzene, 1-fluoro-4-[(4-methylphenyl)thio]-(42917-47-5)

Safety Data

• Hazardous Substances Data: 42917-47-5(Hazardous Substances Data)

Upstream product

• 405-31-2 bis(4-fluorophenyl)disulfide 
• 108-88-3 toluene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 106-45-6 para-thiocresol 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1583-56-8 4-fluorobenzoyl fluoride 
• 371-42-6 4-Fluorothiophenol 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 2714-90-1 phenyl 4-fluorobenzoate 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 460-00-4 1-Bromo-4-fluorobenzene 

Relevant articles and documents

Coupling of thiols and aromatic halides promoted by diboron derived super electron donors

We have proven that pyridine-boryl complexes can be used as superelectron donors to promote the coupling of thiols and aromatic halides through a SRN1 mechanism. The reaction is efficient for a broad substrate scope, tolerating heterocycles including pyridines, enolizable or reducible functional groups. The method has been applied to intermediates in drug synthesis as well as interesting functionalized polythioethers through a controlled and consecutive intramolecular electron transfer process.

Nickel-Catalyzed Decarbonylative Thioetherification of Acyl Fluorides via C-F Bond Activation

Nickel-catalyzed decarbonylative thioetherification of acyl fluorides has been developed. This transformation allows an array of acyl fluorides to react with thiophenols. A wide range of functional groups are well tolerated and the corresponding sulfides can be obtained in good to excellent yields. This protocol provides the formation of diverse carbon-sulfur bonds via a highly efficient decarbonylative process.

Concerted aryl-sulfur reductive elimination from PNP pincer-supported Co(iii) and subsequent Co(i)/Co(iii) comproportionation

This report discloses a combined experimental and computational study aimed at understanding C-S reductive elimination from Co(iii) supported by a diarylamido/bis(phosphine) PNP pincer ligand. Divalent (PNP)Co-aryl complexes could be easily oxidized to five-coordinate Co(iii) derivatives, and anion metathesis provided five-coordinate (PNP)Co(Ar)(SAr′) complexes of Co(iii). In contrast to their previously described (POCOP)Co(Ar)(SAr′) analogs, but similarly to the (PNP)Rh(Ar)(SAr′) and (POCOP)Rh(Ar)(SAr′) analogs, (PNP)Co(Ar)(SAr′) undergo C-S reductive elimination with the formation of the desired diarylsulfide product ArSAr′. DFT studies and experimental observations are consistent with a concerted process. However, in contrast to the Rh analogs, the immediate product of such reductive elimination, the unobserved Co(i) complex (PNP)Co, un-dergoes rapid comproportionation with the (PNP)Co(Ar)(SAr′) starting material to give Co(ii) compounds (PNP)Co-Ar and (PNP)Co-SAr′.