42920-79-6

Upstream product

• 41980-32-9 5,5'-trimethylenedihydantoin 
• 41980-31-8 2,6-dicyanopiperidine 
• 922-54-3 2,6-diaminopimelic acid 
• 501-53-1 benzyl chloroformate 
• 583-93-7 (+/-)-2,6-Diaminopimelic acid 

Downstream Products

• 1227363-58-7 C₃₁H₄₂N₂O₈ 
• 14289-34-0 (S,S)-2,6-diaminopimelic acid 
• 583-93-7 (2R,6R)-2,6-diaminoheptanedioic acid 
• 78057-80-4 N²-1-benzyl-N-(N-lauroyl-L-alanyl)-γ-D-glutamyl>-N⁶-benzyloxycarbonyl-L-2,6-diaminopimelamic acid 
• 55254-25-6 L-2,6-dibenzyloxycarbonylaminopimelic acid mono p-nitrobenzyl ester 
• 78512-64-8 L-2,6-dibenzyloxycarbonylaminopimelic acid dibenzyl ester 
• 78147-49-6 L-2,6-dibenzyloxycarbonylaminopimelic acid monobenzyl ester 
• 78057-77-9 RP 56142 
• 121190-51-0 O¹-p-nitrobenzyl-N²-benzyloxycarbonyl-L-2,6-diaminopimelic acid 
• 78088-48-9 L-2,6-dibenzyloxycarbonylaminopimelamic acid 
• 78082-26-5 N⁶-benzyloxycarbonyl-L-2,6-diaminopimelamic acid 
• 20714-84-5 L-2,6-dibenzyloxycarbonylaminopimelic acid 
• 123628-69-3 L-N,N-diphenyl-2,6-dibenzyloxycarbonylaminopimelamide 
• 102886-93-1 racem.-2,6-bis-benzyloxycarbonylamino-heptanedioic acid diamide 

Relevant academic research and scientific papers

Synthesis of N-succinyl-L, L-diaminopimelic Acid mimetics via selective protection

The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminop

Photocatalytic stereoselective N-cyclization of 2,6-diaminopimelic acid into piperidine-2,6-dicarboxylic acid by an aqueous suspension of activated cadmium(II) sulfide particles

Photoirradiation at a wavelength of >300 nm of a deaerated suspension of cadmium(II) sulfide (CdS) particles in an aqueous solution of a mixture of stereoisomers of 2,6-diaminopimelic acid (DAP; (S,S):(R,S):(R,R) = 1:2:1) produced piperidine-2,6-dicarboxylic acid (PDC) via a redox-combined mechanism including oxidation and reduction by positive holes and photoexcited electrons, respectively. Both the yield and trans:cis ratio of PDC markedly depended on the kinds of CdS photocatalysts, their pre-treatment, and the loading of fine platinum (or its oxide) particles. A CdS photocatalyst prepared by heat treatment of a commercial powder in hexagonal (wurtzite) structure at 1023 K in the presence of a small amount of air gave the highest yield and trans:cis ratio. Analyses of the activated CdS powder by powder X-ray diffraction (XRD), photoluminescence (PL), X-ray photoelectron spectroscopy (XPS), electron paramagnetic resonance (EPR), and BET surface area measurements revealed the formation of sulfur vacancies due to heat treatment, which promote the photoinduced cadmium metal (Cd0) deposition. The Cd0, deposited in situ on the CdS surface and detected by reduction of methylviologen, may act as a reduction site for photoexcited electrons toward a cyclic Schiff base intermediate produced by oxidation of DAP with positive holes followed by deamination and intramolecular condensation. Optically pure (R,R)- or (S,S)-PDCs were prepared successfully by photocatalytic reaction with the activated CdS particles using (R,R)- or (S,S)-DAPs, indicating that stereoselective conversion of organic compounds can be achieved via photocatalytic reaction under controlled conditions.

Synthesis of RP 56142: a New Immunoactive Peptide

RP 56142, a new immunoactive peptide was synthesized on large scale (ca. 500 g) via L-2,6-diaminopimelic acid which was prepared by chemical or biochemical synthesis.The key derivative, N6-benzyloxycarbonyl-L-2,6-diaminopimelamic acid was synthesized by two methods.In the first, we used a copper chelate procedure.In the second, we selectively deblocked the amine at the α-position to the free carboxylic group by the N-carboxyanhydride method.Condensation of N6-benzyloxycarbonyl-L-2,6-diaminopimelamic acid and the appropriately protected lauroyl dipeptide and removal of the protecting groups afforded RP 56142.