638-44-8Relevant articles and documents
Characterization of the promiscuous: N-Acyl CoA transferase, LgoC, in legonoxamine biosynthesis
Alrashdi, Saad,Deng, Hai,Kyeremeh, Kwaku,Maglangit, Fleurdeliz,Renault, Justine,Tong, Ming Him,Trembleau, Laurent,Victoria, Catherine,Wang, Shan
supporting information, p. 2219 - 2222 (2020/04/07)
More than 500 siderophores are known to date, but only three were identified to be aryl-containing hydroxamate siderophores, legonoxamines A and B from Streptomyces sp. MA37, and aryl ferrioxamine 2 from Micrococcus luteus KLE1011. Siderophores are produced by microorganisms to scavenge iron from the environment, thereby making this essential metal nutrient available to the microbe. We demonstrate here that LgoC from MA37 is responsible for the key aryl-hydroxamate forming step in legonoxamine biosynthesis. Biochemical characterization established that LgoC displays considerable promiscuity for the acylation between N-hydroxy-cadaverine and SNAC (N-Acetylcysteamines) thioester derivatives.
Oxidative Formation of Disulfide Bonds by a Chemiluminescent 1,2-Dioxetane under Mild Conditions
Sauer, Caroline S.,K?ckenberger, Johannes,Heinrich, Markus R.
supporting information, p. 9331 - 9338 (2020/08/14)
The oxidation of alkyl thiols to disulfides has been achieved under mild conditions using a chemiluminescent 1,2-dioxetane as a stoichiometric oxidant. Besides the mild and biocompatible reaction conditions, this approach offers the possibility to monitor the presence of thiols through oxidation and chemiluminescence of the remaining dioxetane.
CHIRAL CONTROL
-
Paragraph 0017; 0076, (2014/02/15)
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same.