43008-86-2Relevant academic research and scientific papers
Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides
Gao, Nanxing,Li, Yanshun,Teng, Dawei
, p. 3569 - 3572 (2022/02/11)
The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for th
Nickel-catalyzed C-N bond activation: Activated primary amines as alkylating reagents in reductive cross-coupling
Yue, Huifeng,Zhu, Chen,Shen, Li,Geng, Qiuyang,Hock, Katharina J.,Yuan, Tingting,Cavallo, Luigi,Rueping, Magnus
, p. 4430 - 4435 (2019/04/29)
Nickel-catalyzed reductive cross coupling of activated primary amines with aryl halides under mild reaction conditions has been achieved for the first time. Due to the avoidance of stoichiometric organometallic reagents and external bases, the scope regarding both coupling partners is broad. Thus, a wide range of substrates, natural products and drugs with diverse functional groups are tolerated. Moreover, experimental mechanistic investigations and density functional theory (DFT) calculations in combination with wavefunction analysis have been performed to understand the catalytic cycle in more detail.
Copper-Catalyzed Boron-Selective C(sp2)-C(sp3) Oxidative Cross-Coupling of Arylboronic Acids and Alkyltrifluoroborates Involving a Single-Electron Transmetalation Process
Ding, Siyi,Xu, Liang,Li, Pengfei
, p. 1329 - 1333 (2016/02/18)
A rapid and highly selective oxidative cross-coupling reaction between readily available and shelf-stable arylboronic acids and primary or secondary potassium alkyltrifluoroborates was devised and developed, which works under mild conditions using copper(II) acetate as the catalyst and silver oxide as the oxidant. Initial experimental results indicate that a single-electron transmetalation process is involved. This approach effectively bypasses the problems associated with the traditional cross-coupling reactions of alkylboronates and thus provides a complementary method in building C(sp2)-C(sp3) bonds.
