43053-57-2Relevant articles and documents
Asymmetric Epoxidation of Enones Promoted by Dinuclear Magnesium Catalyst
Jaszczewska-Adamczak, Joanna A.,Mlynarski, Jacek
supporting information, p. 4247 - 4255 (2021/07/17)
Asymmetric synthesis with cheaper and non-toxic alkaline earth metal catalysts is becoming an important and sustainable alternative to conventional catalytic methodologies mostly relying on precious metals. In spite of some sustainable methods for enantioselective epoxidation of enones, the development of a well-defined and efficient catalyst based on magnesium complexes for these reactions is still a challenging task. In this perspective, we present the application of chiral dinuclear magnesium complexes for asymmetric epoxidation of a broad range of electron-deficient enones. We demonstrate that the in situ generated magnesium-ProPhenol complex affords enantioenriched oxiranes in high yields and with excellent enantioselectivities (up to 99% ee). Our extensive study verifies the literature data in this area and provides a step forward to better understand the factors controlling the oxygenation process. Elaborated catalyst offers mild reaction conditions and a truly wide substrate scope. (Figure presented.).
Asymmetric epoxidation of 2-arylidene-1,3-diketones: Facile access to synthetically useful epoxides
Russo, Alessio,Lattanzi, Alessandra
experimental part, p. 2633 - 2638 (2010/07/16)
In this article the first enantioselective epoxidation reaction of acyclic and cyclic 2-arylidene-1,3-diketones is reported. Easily accessible or commercially available α,α-diaryl prolinols as the organocatalysts in the presence of tert-butyl hydroperoxid
A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases
Yu, Xiang Y.,Finn, John,Hill, Jason M.,Wang, Zhong G.,Keith, Dennis,Silverman, Jared,Oliver
, p. 1339 - 1342 (2007/10/03)
We have identified a series of spirocyclic furan and pyrrolidine inhibitors of Enterococeus faecalis and Staphylococcus aureus phenylalanyl-tRNA synthetases. The most potent analogue 1b showed IC50=5 nM (E. faecalis PheRS) and IC50=2
Discovery of the first series of inhibitors of human papillomavirus type 11: Inhibition of the assembly of the E1-E2-Origin DNA complex
Yoakim, Christiane,Ogilvie, William W.,Goudreau, Nathalie,Naud, Julie,Hache, Bruno,O'Meara, Jeff A.,Cordingley, Michael G.,Archambault, Jacques,White, Peter W.
, p. 2539 - 2541 (2007/10/03)
We have discovered a series of inhibitors of the assembly of the HPV11 E1-E2-origin DNA complex, which incorporate an indandione fused to a substituted tetrahydrofuran.
Heterocycles as antimicrobial agents
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, (2008/06/13)
Methods for treating infection and related compositions, compounds of formula I as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit transfer ribonucleic acid (tRNA) synthetase and are useful as ant