43067-41-0

Basic information

• Product Name: 5,7-DIMETHYL-1H-INDAZOLE
• Synonyms: 5,7-DIMETHYL-1H-INDAZOLE;5,7-dimethyl-1H-indazole(SALTDATA: FREE);6,7-dimethyl benzo(1,2-c)imidazole;1H-Indazole, 5,7-dimethyl-
• CAS NO: 43067-41-0
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.19
• Mol File: 43067-41-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 171-172 °C
• Boiling Point: 299.9°C at 760 mmHg
• Flash Point: 138.1°C
• Appearance: /
• Density: 1.145g/cm³
• Vapor Pressure: 0.00207mmHg at 25°C
• Refractive Index: 1.644
• PKA: 14.62±0.40(Predicted)
• CAS DataBase Reference: 5,7-DIMETHYL-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DIMETHYL-1H-INDAZOLE(43067-41-0)
• EPA Substance Registry System: 5,7-DIMETHYL-1H-INDAZOLE(43067-41-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 43067-41-0(Hazardous Substances Data)

Usage

General Description

5,7-Dimethyl-1H-indazole is a chemical compound with the molecular formula C10H10N2. It is a substituted indazole derivative, which is a bicyclic aromatic heterocycle containing a five-membered nitrogen-containing ring fused to a six-membered carbon ring. 5,7-DIMETHYL-1H-INDAZOLE is primarily used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other industrial products. It is also known for its potential biological activities, including as an antimicrobial and anti-inflammatory agent. 5,7-Dimethyl-1H-indazole is a colorless to pale yellow liquid with a slightly aromatic odor, and it is considered to be of low toxicity.

InChI:InChI=1/C9H10N2/c1-6-3-7(2)9-8(4-6)5-10-11-9/h3-5H,1-2H3,(H,10,11)

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 333-20-0 potassium thioacyanate 
• 14213-00-4 2,4,6-trimethylaniline azide 
• 1379655-58-9 [MesBC₄Ph₄(C₆H₆)] 
• 64-17-5 ethanol 
• 19080-14-9 (Z)-2,4,6-Trimethylphenylazo tert-butylsulfide 
• 67-64-1 acetone 

Downstream Products

• 1414526-78-5 C₂₇H₁₀BF₁₅N₂ 
• 847906-31-4 3-iodo-5,7-dimethyl-1H-indazole 
• 857800-75-0 1-acetyl-5,7-dimethyl-1H-indazole 
• 93832-50-9 2,5,6-trifluoro-4-(2,4,6-trimethylphenylazo)pyrimidine 

Relevant articles and documents

Formation of BN Isosteres of Azo Dyes by Ring Expansion of Boroles with Azides

Herein, we present the results of our investigations on the effect of ortho substitution of aryl azides on the ring-expansion reaction of boroles, five-membered unsaturated boron heterocycles. These studies led to the isolation of the first 1,2-azaborinin

Behaviour of Arylazo tert-Butyl Sulfides with Ketone Enolates. Competition between SRN1 α-Arylation and Azocoupling Reactions.

(Z)-Arylazo tert-butyl sulfides 1a-i react, in DMSO and at room temperature, with potassium acetone enolate to give good yields of 1-aryl-2-propanones via spontaneous SRN1 dark reactions. α-Phenylation of pincolone and acetophenone enolates by 1a likewise occurs in excellent yields.In agreement with the involvement of an electron-transfer catalyzed chain process, the reaction of the 4-bromo derivative 1n with pinacolone enolate gives mainly the bis-substitution product 13.With azosulfides 1j-m the arylation pathway competes with a base-induced thiol elimination eventually leading, depending on the structure of the azosulfide, to indazoles 8 or 11 and/or to 2-oxopropanal arylhydrazones 9, 10 or 12.