43135-91-7

Usage

Uses

Used in Pharmaceutical Industry:
Benzimidazol-2-one is used as a key component in the synthesis of various pharmaceutical compounds for its potential biological activities. It is utilized for its antiviral, antitumor, and antimicrobial properties, making it a valuable asset in the development of new drugs to combat various diseases and infections.
Used in Organic Synthesis:
Benzimidazol-2-one is used as a building block in organic synthesis, contributing to the creation of a wide range of chemical compounds. Its versatile structure allows for the development of new molecules with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, benzimidazol-2-one is employed for its potential to contribute to the discovery and development of new drugs. Its unique structure and biological activities make it an important compound in the design and synthesis of novel therapeutic agents.
Used in Drug Discovery:
Benzimidazol-2-one plays a crucial role in drug discovery, where it is used to explore its potential as a therapeutic agent. Its antiviral, antitumor, and antimicrobial properties make it a promising candidate for the development of new treatments for various diseases and conditions.

InChI:InChI=1/C7H4N2O/c10-7-8-5-3-1-2-4-6(5)9-7/h1-4H

Upstream product

• 273-13-2 benzo[1,2,5]thiadiazole 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 94-09-7 p-aminoethylbenzoate 
• 95-54-5 1,2-diamino-benzene 
• 88-74-4 2-nitro-aniline 
• 96-31-1 N,N'-Dimethylurea 
• 124-38-9 carbon dioxide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 57-13-6 urea 
• 177858-78-5 6-chloro-1-(2-mesyloxyethyl)-1,3-dihydro-2H-benzimdazol-2-one 
• 2735-73-1 1,3-diacetyl-1,3-dihydro-benzoimidazol-2-one 

Downstream Products

• 39936-67-9 1,3-bis(2-hydroxyethyl)-1H-benzo[d]imidazol-2(3H)-one 
• 52203-81-3 1,3-bis(hydroxymethyl)benzimidazolin-2-one 

Relevant academic research and scientific papers

Optimisation by design of experiment of benzimidazol-2-one synthesis under flow conditions

A novel flow-based approach for the preparation of benzimidazol-2-one (1) scaffold by the 1,10-carbonyldiimidazole (CDI)-promoted cyclocarbonylation of o-phenylenediamine (2) is reported. Starting from a preliminary batch screening, the model r

Method for preparing carbonyl heterocyclic compound

The invention provides a method for preparing a carbonyl heterocyclic compound, wherein Lewis base and hydrosilane are used as accelerators and can efficiently enable an ortho-substituted aniline compound to react with normal-pressure CO2 to generate corresponding carbonyl heterocyclic compounds containing different functional groups under mild conditions (100 DEG C, digital). According to the method, normal-pressure CO2 is used as an environmentally-friendly non-toxic carbonylation reagent, and cheap Lewis base and PMHS (industrial silicon waste) are used as accelerators, so that the use of CO, high-pressure CO2 and noble metal catalysts is avoided, the intermediate isocyanate does not need to be purified and separated, the pure product can be obtained only through simple suction filtration and separation after the reaction is finished, and the synthetic method is efficient and universal, is suitable for preparing a series of benzimidazolone, benzoxazolone and benzothiazolone compounds and has high industrial application value.

A 5-acetoactylaminobenzimidazolon preparation method (by machine translation)

The present invention provides a 5-acetoactylaminobenzimidazolon preparation method, comprising the following steps: under the action of the acid catalyst, will 5-amino-benzimidazolone, double-ketene, alcohol and water to the reaction, the 5-acetoactylaminobenzimidazolon; the alcohol is methanol, ethanol and propanol in one or several kinds of. The present invention provides a method of preparing 5-acetoactylaminobenzimidazolon in the production process, the reaction temperature of the acetylation process, thus reducing the equipment requirements, and also reducing the risk of the coefficient in the actual production, the mild reaction conditions, is easy to operate. (by machine translation)

Au catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO 2/H2

The gold-catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO2 in the presence of H2 was reported, and a series of benzimidazoles were obtained under relatively mild conditions. Several supported Au catalysts including Au/TiO2, Au/Al2O3, Au/ZnO, Au/polyurea and Au/hydrotalcite were examined for the synthesis of benzimidazole from the reaction of 2-nitroaniline with CO2 and H 2, among which Au/TiO2 displayed the best performance. The reaction mechanism was investigated, and it was found that the production of benzimidazole underwent the formation of o-phenylenediamine via the hydrogenation of 2-nitroaniline, followed by the cyclization of o-phenylenediamine with CO2 and H2. This work provides a CO2-involved route for the synthesis of benzimidazoles, which may widen the applications of CO2 in the chemical synthesis. This journal is the Partner Organisations 2014.

Samarium diiodide mediated regeneration of 1,2-benzenediamine and preparation of benzimidazolin-2-ones from 2,1,3-benzothiadiazoles

On treatment with Sml3 in THF and in the presence of methanol, 2,1,3-benzothiadiazoles underwent reductive N-S bond cleavage leading to 1,2-benzenediamines in high yields. Without methanol but in the presence of triphosgene, benzimidazolin-2-ones were obtained in moderate yields under mild conditions.

Substituted amino methyl factor Xa inhibitors

The present application describes substituted-aminomethyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.

Compounds useful in therapy

There is provided a compound of formula I, wherein Het1, T, X, R1, R2and R3have meanings given in the description, which are useful in the prophylaxis and in the treatment of diseases mediated by opiate receptors, such as pruritus.

Method for manufacturing pigment dispersed liquid, and pigment dispersed liquid, and ink for ink-jet printer recording using said pigment dispersed liquid

A method for manufacturing a pigment dispersed liquid, comprising at least: Step A of introducing a hydrophilic dispersibility-imparting group directly and/or via another atomic group to the surface of pigment particles; Step B of dispersing the pigment o

Heteroaryl-phenyl substituted factor Xa inhibitors

The present application describes heteroaryl-phenyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of factor Xa.

Heteroaryl- phenyl heterobicyclic factor Xa inhibitors

The present application describes heteroaryl-phenyl heterobicycles and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.