43135-91-7

Basic information

• Product Name: benzimidazol-2-one
• Synonyms: BENZIMIDAZOLONE;benzimidazol-2-one;2H-Benzo[d]iMidazol-2-one
• CAS NO: 43135-91-7
• Molecular Formula: C₇H₄N₂O
• Molecular Weight: 132.12
• Mol File: 43135-91-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 249.3 °C at 760 mmHg
• Flash Point: 98.6 °C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 0.0232mmHg at 25°C
• Refractive Index: 1.701
• CAS DataBase Reference: benzimidazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: benzimidazol-2-one(43135-91-7)
• EPA Substance Registry System: benzimidazol-2-one(43135-91-7)

Safety Data

• Hazardous Substances Data: 43135-91-7(Hazardous Substances Data)

Usage

General Description

Benzimidazol-2-one is a chemical compound with the molecular formula C7H6N2O. It is a heterocyclic compound that contains a benzene ring fused to an imidazole ring with a ketone functional group at position 2. Benzimidazol-2-one is a key component in the synthesis of various pharmaceutical compounds and is known for its potential biological activities, including antiviral, antitumor, and antimicrobial properties. benzimidazol-2-one has been extensively studied for its potential therapeutic applications and continues to be of interest to researchers in the pharmaceutical and medical fields. Additionally, benzimidazol-2-one is used as a building block in organic synthesis and medicinal chemistry, making it an important and versatile chemical in drug discovery and development.

InChI:InChI=1/C7H4N2O/c10-7-8-5-3-1-2-4-6(5)9-7/h1-4H

Upstream product

• 273-13-2 benzo[1,2,5]thiadiazole 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 94-09-7 p-aminoethylbenzoate 
• 2735-73-1 1,3-diacetyl-1,3-dihydro-benzoimidazol-2-one 
• 95-54-5 1,2-diamino-benzene 
• 88-74-4 2-nitro-aniline 
• 96-31-1 N,N'-Dimethylurea 
• 124-38-9 carbon dioxide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 57-13-6 urea 
• 177858-78-5 6-chloro-1-(2-mesyloxyethyl)-1,3-dihydro-2H-benzimdazol-2-one 

Downstream Products

• 52203-81-3 1,3-bis(hydroxymethyl)benzimidazolin-2-one 
• 39936-67-9 1,3-bis(2-hydroxyethyl)-1H-benzo[d]imidazol-2(3H)-one 

Relevant articles and documents

Optimisation by design of experiment of benzimidazol-2-one synthesis under flow conditions

A novel flow-based approach for the preparation of benzimidazol-2-one (1) scaffold by the 1,10-carbonyldiimidazole (CDI)-promoted cyclocarbonylation of o-phenylenediamine (2) is reported. Starting from a preliminary batch screening, the model r

A 5-acetoactylaminobenzimidazolon preparation method (by machine translation)

The present invention provides a 5-acetoactylaminobenzimidazolon preparation method, comprising the following steps: under the action of the acid catalyst, will 5-amino-benzimidazolone, double-ketene, alcohol and water to the reaction, the 5-acetoactylaminobenzimidazolon; the alcohol is methanol, ethanol and propanol in one or several kinds of. The present invention provides a method of preparing 5-acetoactylaminobenzimidazolon in the production process, the reaction temperature of the acetylation process, thus reducing the equipment requirements, and also reducing the risk of the coefficient in the actual production, the mild reaction conditions, is easy to operate. (by machine translation)

Samarium diiodide mediated regeneration of 1,2-benzenediamine and preparation of benzimidazolin-2-ones from 2,1,3-benzothiadiazoles

On treatment with Sml3 in THF and in the presence of methanol, 2,1,3-benzothiadiazoles underwent reductive N-S bond cleavage leading to 1,2-benzenediamines in high yields. Without methanol but in the presence of triphosgene, benzimidazolin-2-ones were obtained in moderate yields under mild conditions.