43156-48-5

Basic information

• Product Name: 5-PHENYLTHIO-1,2-DIAMINOBENZENE
• Synonyms: 5-PHENYLTHIO-1,2-DIAMINOBENZENE;4-(phenylthio)benzene-1,2-diamine;3,4-DIAMINODIPHENYLSULFIDE;4-(Phenylthio)-1,2-benzenediamine;4-(Phenylthio)-o-phenylenediamine;4-Phenylsulfenyl-o-phenylenediamine;4-Thiophenoxy-1,2-phenylenediamine
• CAS NO: 43156-48-5
• Molecular Formula: C₁₂H₁₂N₂S
• Molecular Weight: 216.3
• EINECS: 256-122-1
• Product Categories: Benzene derivates
• Mol File: 43156-48-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 441.5°Cat760mmHg
• Flash Point: 220.8°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 5.41E-08mmHg at 25°C
• Refractive Index: 1.707
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.36±0.10(Predicted)
• Stability: Air Sensitive
• CAS DataBase Reference: 5-PHENYLTHIO-1,2-DIAMINOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYLTHIO-1,2-DIAMINOBENZENE(43156-48-5)
• EPA Substance Registry System: 5-PHENYLTHIO-1,2-DIAMINOBENZENE(43156-48-5)

Safety Data

• Hazardous Substances Data: 43156-48-5(Hazardous Substances Data)

Usage

Uses

4-(Phenylthio)-1,2-benzenediamine is used in the synthesis of bis(2-chloroethyl)aminophosphoryl-containing compounds which are potential anticancer agents. It is also used in the synthesis of 2-substituted-2,3-dihyrdro-5-thiophenoxy-1H-1,3,2-benzodiazaphosphole 2-oxides which exhibit antimicrobial activity.

InChI:InChI=1/C12H12N2S/c13-11-7-6-10(8-12(11)14)15-9-4-2-1-3-5-9/h1-8H,13-14H2

Upstream product

• 930-69-8 sodium thiophenolate 
• 54029-45-7 2-nitro-4-thiocyanoaniline 
• 89-63-4 4-Chloro-2-nitroaniline 
• 108-42-9 3-chloro-aniline 
• 5228-61-5 5-bromo-2-nitroaniline 
• 106-37-6 1.4-dibromobenzene 
• 51686-78-3 2,4-dibromonitrobenzene 
• 92114-64-2 2-nitro-4-(phenylthio)aniline 
• 611-06-3 2,4-dichloronitrobenzene 
• 541-73-1 1,3-Dichlorobenzene 
• 43156-47-4 2-nitro-5-phenylthioaniline 
• 5443-33-4 N-(5-chloro-2-nitrophenyl)acetamide 
• 108-98-5 thiophenol 
• 1635-61-6 5-chloro-2-nitroaniline 

Downstream Products

• 43156-47-4 2-nitro-5-phenylthioaniline 
• 54394-05-7 1,2-bis-(3-carbomethoxy-2-thioureido)-4-phenylthiobenzene 
• 43210-67-9 fenbendazole 
• 43210-67-9 Fenbendazole 
• 129165-89-5 [6-(5-Phenylsulfanyl-1H-benzoimidazol-2-ylcarbamoyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester 
• 129165-85-1 4-Acetylamino-3-nitro-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-benzamide 
• 129165-87-3 4-Amino-3-nitro-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-benzamide 
• 125422-50-6 2-(1-Pyrrolidinoacetylamino)-5⁽⁶⁾-phenylsulphonobenzimidazole 
• 125422-36-8 2-Acetamido-5⁽⁶⁾-(3-nitro-5-phenylsulphono)-benzimidazole 
• 125422-44-8 2-Morpholin-4-yl-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide 
• 125422-47-1 2-(4-Methyl-piperidin-1-yl)-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide 
• 125422-45-9 2-(2-Methyl-piperidin-1-yl)-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide 
• 125422-46-0 2-(3-Methyl-piperidin-1-yl)-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide 
• 125422-40-4 1-(3-Methyl-piperidin-1-yl)-2-(5-phenylsulfanyl-1H-benzoimidazol-2-ylamino)-ethanone 

Relevant articles and documents

Synthetic method of fenbendazole

A synthetic method of fenbendazole belongs to the technical field of insect repellents, and specifically comprises the following steps: carrying out condensation reaction on 5-chloro-2-nitroaniline and a sodium thiophenol aqueous solution in a mixed solution of n-propyl alcohol and water to obtain 5-thiophenyl-2-nitroaniline; carrying out reduction reaction on the 5-thiophenyl-2-nitroaniline in a high-pressure kettle under the catalysis of raney nickel to generate 4-thiophenyl o-phenylenediamine; and mixing the 4-thiophenyl o-phenylenediamine and N-(trichloromethyl) methyl carbamate for a cyclization reaction to obtain fenbendazole; the method has the advantages that conditions are mild, operation is easy and convenient, ammonium chloride can be prevented from being generated in the cyclization process, and the three-waste cost is low; the generation of amine salt is avoided, and the treatment cost of three wastes is greatly reduced; and the yield of the fenbendazole can reach 84.27% to 89.99%, and the purity of the fenbendazole can reach 96.39% to 99.71%.

Preparation method of 4-thiophenyl-o-phenylenediamine

The invention provides a preparation method of 4-thiophenyl-o-phenylenediamine, wherein the preparation method comprises the steps: by taking 2-nitro-4-thiocyano aniline and aniline as initial raw materials, firstly, reacting 2-nitro-4-thiocyano aniline with sodium sulfide to obtain 3-nitro-4-amino thiophenol sodium, and reacting aniline with sodium nitrite under an acidic condition to generate benzene diazonium chloride; and then condensing the benzene diazonium chloride and the 3-nitro-4-amino thiophenol sodium to obtain 2-nitro-4-thiophenyl aniline, and then carrying out a Raney nickel hydrogenation reduction reaction to obtain the 4-thiophenyl-o-phenylenediamine. The method has the characteristics of high economic benefit, low three-waste amount, low cost and the like, the total yield can reach 64.58%, and the method belongs to the technical field of organic chemical industry.

A preparation method of curing melanotumor

The invention discloses a preparation method of fenbendazole and provides a brand-new synthesis route of the fenbendazole. The fenbendazole is prepared from m-dichlorobenzene as a starting material through the steps of nitrification, condensation, amination, reduction and cyclization. The preparation method is characterized in that the starting material m-chloroaniline in the existing industrial route is changed to the cheap m-dichlorobenzene; the existing reduction technology with sodium sulfide dihydrate is changed to the clean and high-efficiency reduction technology; and the new synthesis technology is concise and simple, high in efficiency, slight in pollution, high in quality, and suitable to industrial production.