43229-87-4

Basic information

• Product Name: Benzenepropanoic acid, 4-cyano-.alpha.-oxo-
• Synonyms: Benzenepropanoic acid, 4-cyano-.alpha.-oxo-;4-Cyano-a-oxo-benzenepropanoic acid;3-(4-Cyano-phenyl)-2-oxo-propionic acid
• CAS NO: 43229-87-4
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.16748
• Mol File: 43229-87-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenepropanoic acid, 4-cyano-.alpha.-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, 4-cyano-.alpha.-oxo-(43229-87-4)
• EPA Substance Registry System: Benzenepropanoic acid, 4-cyano-.alpha.-oxo-(43229-87-4)

Safety Data

• Hazardous Substances Data: 43229-87-4(Hazardous Substances Data)

Upstream product

• 18664-39-6 3-(4-cyanophenyl)acrylic acid 
• 18910-26-4 2-amino-3-(4-cyano-phenyl)-propionic acid 
• 654055-09-1 3-(4-cyano-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid 

Downstream Products

• 246542-33-6 4-{[6-(1-amino-cyclopropyl)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl)-methyl]-benzonitrile 
• 246542-32-5 4-{[6-(1-(N-tert-butyloxycarbonylamino)-cyclopropyl)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl)-methyl]-benzonitrile 
• 246542-34-7 4-{[6-(1-cyclopentylamino-cyclopropyl)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}-benzonitrile 
• 592465-38-8 4-{4-methyl-3-oxo-7-[1-(pyrrolidine-1-carbonyl)-cyclopropyl]-3,4-dihydro-quinoxalin-2-ylmethyl}-benzonitrile 
• 246542-35-8 N-{1-[3-(4-cyano-benzyl)-1-methyl-2-oxo-1,2-dihydro-quinoxalin-6-yl]-cyclopropyl}-N-cyclopentyl-malonamic acid ethyl ester 
• 777044-08-3 N-{1-[3-(4-carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-dihydro-quinoxalin-6-yl]-cyclopropyl}-N-cyclopentyl-malonamic acid ethyl ester 
• 236418-15-8 4-[(6-(1-carboxy-cyclopropan-1-yl)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl)-methyl]-benzonitrile 

Relevant articles and documents

Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process

The synthesis of substituted D-phenylalanines in high yield and excellent optical purity, starting from inexpensive cinnamic acids, has been achieved with a novel one-pot approach by coupling phenylalanine ammonia lyase (PAL) amination with a chemoenzymatic deracemization (based on stereoselective oxidation and nonselective reduction). A simple high-throughput solid-phase screening method has also been developed to identify PALs with higher rates of formation of non-natural D-phenylalanines. The best variants were exploited in the chemoenzymatic cascade, thus increasing the yield and ee value of the D-configured product. Furthermore, the system was extended to the preparation of those L-phenylalanines which are obtained with a low ee value using PAL amination.

Antithrombotic quinoxazolines

Quinoxazolines having antithrombotic activity. Exemplary of those disclosed are: 4-{[6-(N-carboxymethyl-quinolin-8-yl-sulphonylamino)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}-benzamidine, 4-{[6-(1-(N-cyclopentyl-carboxymethylcarbonylamino)-cyclo-propyl)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}-benzamidine, and 4-{[7-(N-carboxymethylaminocarbonyl-ethylamino)-4-methyl-quinolin-2-yl]-oxo}-benzamidine.