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Usage

Uses

Used in Pharmaceutical Industry:
6-Hydroxykaempferol is used as a therapeutic agent for its antioxidant and anti-inflammatory properties, which may help protect against oxidative stress and reduce inflammation in the body.
Used in Anticancer Applications:
6-Hydroxykaempferol is used as an anticancer agent, particularly against solid malignancies such as breast and lung cancers. It has been investigated for its potential to inhibit the growth of cancer cells, making it a promising candidate for cancer treatment and prevention.
Used in Nutraceutical Industry:
6-Hydroxykaempferol is used as a dietary supplement or functional food ingredient due to its health-promoting properties, including its antioxidant and anti-inflammatory effects, which may contribute to overall wellness and disease prevention.
Used in Cosmetic Industry:
6-Hydroxykaempferol is used as an active ingredient in skincare products for its potential to protect the skin from oxidative stress and reduce inflammation, which may help improve skin health and appearance.
Used in Food and Beverage Industry:
6-Hydroxykaempferol is used as a natural preservative or functional ingredient in food and beverage products to leverage its antioxidant properties, potentially extending shelf life and enhancing health benefits.
Used in Research and Development:
6-Hydroxykaempferol is used as a subject of ongoing research in the field of natural medicine and pharmacology, with the aim of further exploring its therapeutic potential and developing novel applications for the treatment and prevention of various diseases.

InChI:InChI=1/C15H10O7/c16-7-3-1-6(2-4-7)15-14(21)13(20)10-9(22-15)5-8(17)11(18)12(10)19/h1-5,16-19,21H

Upstream product

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• 14639-73-7 1-(3,6-dihydroxy-2,4-dimethoxy-phenyl)-2-methoxy-ethanone 
• 100059-77-6 1-(2,6-dihydroxy-3,4-dimethoxy-phenyl)-2-methoxy-ethanone 
• 41929-26-4 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)propenone 
• 17742-46-0 acetic acid 3,4,5-trimethoxy-phenyl ester 
• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 642-71-7 3,4,5-trimethoxyphenol 
• 84019-17-0 5,6-dihydroxy-3,7,4′-trimethoxyflavonol 
• 5867-71-0 3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone 
• 111316-43-9 6-hydroxy-3,5,7-trimethoxy-2-(4-methoxy-phenyl)-chromen-4-one 

Relevant academic research and scientific papers

Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase

Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxykaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxyflavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, we conclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agents with inhibitory effects in addition to their antioxidant properties.

Studies of the selective O-alkylation and dealkylation of flavonoids. XVIII. A convenient method for synthesizing 3,5,6,7-tetrahydroxyflavones

In the demethylation of 6-hydroxy-3,4',7-trimethoxy-5-(tosyloxy)flavone with anhydrous aluminum bromide, the 5-tosyloxyl group was eliminated with bromination to give 8-bromo-3,6,7-trihydroxy-4'-methoxyflavone as the main product. When anhydrous aluminum chloride was used in the demethylation of the acetate, the 5-tosyloxyl group was cleaved prior to the demethylation to give 5,6,7-trihydroxy-3,4'-dimethoxyflavone. Demethylation of 6-hydroxy-4',5,7-trimethoxy-3-(tosyloxy)flavone and its acetate with the bromide or chloride afforded the 5,6,7-trihydroxyflavone without the cleavage of the 3-tosyloxyl group, but was not suitable for the general synthesis of the 3,5,6,7-tetrahydroxyflavones because of the difficulty in removing the protecting group. Consequently, it was found that the direct demethylation of 3,6-dihydroxy-5,7-dimethoxyflavones with anhydrous aluminum chloride-sodium iodide in acetonitrile was the most useful general method for synthesizing 3,5,6,7-tetrahydroxyflavones. Additionally, the reported structures of two natural flavones were revised.