4333-82-8Relevant academic research and scientific papers
Pd-catalyzed cross-coupling of highly sterically congested enol carbamates with grignard reagents via c-o bond activation
Chen, Zicong,So, Chau Ming
, p. 3879 - 3883 (2020/06/08)
The palladium-catalyzed cross-coupling reaction of enol carbamates to construct highly sterically congested alkenyl compounds is presented for the first time. This protocol demonstrates the potential of using thermally stable and highly atom-economic enol electrophiles as building blocks in bulky alkene synthesis. This reaction accommodates a broad substrate scope with excellent Z/E isomer ratios, which also provides a new synthetic pathway for accessing Tamoxifen.
Microwave-assisted, Pd(0)-catalyzed cross-coupling of diazirines with aryl halides
Zhao, Xia,Wu, Guojiao,Yan, Chong,Lu, Kui,Li, Hui,Zhang, Yan,Wang, Jianbo
supporting information; experimental part, p. 5580 - 5583 (2011/02/23)
Pd(0)-catalyzed cross-coupling reactions of diazirines with aryl halides under microwave heating conditions afford a series of substituted olefins. A reaction mechanism involving the migratory insertion of the Pd carbene intermediate is proposed.
Efficient mono- and dilithiation of 2-bromo-1,1-diphenylethene with n-butyllithium/tetramethylethylenediamine
Korneev, Sergei M.,Kaufmann, Dieter E.
, p. 491 - 496 (2007/10/03)
Lithiation of 2-bromo-1,1-diphenylethene (2) with n-butyllithium or tert-butyllithium/tetramethylethylenediamine (TMEDA) in pentane at -100°C effects a halogen-lithium exchange to give 2-lithio-1,1-diphenylethene (3) exclusively, which reacts with electrophiles to provide 2-substituted-1,1-diphenylethenes 5-8 in high yields. Further lithiation of the monolithium derivative 3 with n-butyllithium/TMEDA results in the direct ortho-lithiation of Z-located phenyl ring to give dilithium derivative 9, which forms disubstituted ethenes 11-13 or heterocycles 15-17 on treatment with electrophiles, tert-Butyllithium/TMEDA is ineffective for the second lithiation step.
Method of treating filariae
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, (2008/06/13)
The present invention relates to a novel method for treating a mammal suffering from filariae.
Formation and rearrangement of gem-dilithiodiphenylethene
Maercker, Adalbert,Boes, Benno,Hajgholipour, Mohammad Taghi
, p. 143 - 149 (2007/10/03)
1,1-Dilithio-2,2-diphenylethene (14) is accessible through double bromine lithium exchange reaction starting from 1,1-dibromo-2,2-diphenylethene (5) with lithium metal at -110°C. 14 undergoes rearrangement into (E)-1-lithio-2-(2-lithiophenyl)-2-phenylethene (13) at temperatures above -100°C. The (Z)-compound 15 was formed from the (E)-compound 13 at temperatures above -25°C.
