4345-16-8

Upstream product

• 26251-08-1 2-nitro-1-phenylpropan-1-ol 
• 42407-55-6 (1RS,2RS)-2-dibenzylamino-1-phenyl-propan-1-ol; hydrochloride 
• 100-52-7 benzaldehyde 
• 532-28-5 (RS)-mandelonitrile 
• 910471-77-1 2-(tert-butyldiphenylsilyloxy)-2-phenylacetonitrile 
• 38222-78-5 threo-1-benzoyloxy-1-phenyl-2-propylammonium chloride 
• 154-41-6 erythro-1-phenyl-1-hydroxy-2-propylammonium chloride 
• 4380-71-6 erythro-2-benzoylamino-1-phenylpropan-1-ol 
• 38222-77-4 trans-2,5-diphenyl-4-methyl-1,3-oxazoline 

Downstream Products

• 4380-71-6 erythro-2-benzoylamino-1-phenylpropan-1-ol 
• 39861-30-8 2-chloro-1-methyl-2-phenyl-ethylamine; hydrochloride 
• 38222-78-5 threo-1-benzoyloxy-1-phenyl-2-propylammonium chloride 
• 1630-31-5 trans-5-phenyl-4-methyl-1,3-thiazolidine-2-thione 
• 78393-88-1 erythro-1-chloro-1-phenyl-2-isothiocyanatopropane 
• 78393-88-1 threo-1-chloro-1-phenyl-2-isothiocyanatopropane 
• 78373-96-3 trans-5-phenyl-2-methoxy-4-methyl-1,3-thiazoline 
• 78373-96-3 cis-5-phenyl-2-methoxy-4-methyl-1,3-thiazoline 
• 78374-02-4 trans-2-diethylamino-5-phenyl-4-methyl-1,3-thiazoline 
• 78374-02-4 cis-2-diethylamino-5-phenyl-4-methyl-1,3-thiazoline 
• 78374-00-2 trans-5-phenyl-2-phenylamino-4-methyl-1,3-thiazoline 
• 78374-00-2 cis-5-phenyl-2-phenylamino-4-methyl-1,3-thiazoline 
• 154-41-6 threo-1-phenyl-1-hydroxy-2-propylammonium chloride 
• 1592-59-2 erythro-1-chloro-1-phenyl-2-propylammonium chloride 

Relevant academic research and scientific papers

Simple preparation process of syn phenylpropanolamines from racemic O-TBDPS cyanohydrins

In this article, a practically interesting route for the diastereoselective synthesis of phenylpropanolamines has been demonstrated for the first time. Using racemic O-tert-butyldiphenylsilyl (TBDPS) cyanohydrins as the starting materials, various syn phenylpropanolamines and derivatives (e.g., norpseudophedrine) have been successfully prepared in exellent diastereoselectivity via a practically interesting process.

STEREOCHEMICAL COURSE OF THE REACTION OF 2-HALOETHYL ISOTHIOCYANATES WITH NUCLEOPHILES. sTEREOSPECIFIC ROUTE TO 4,5-DISUBSTITUTED Δ2-THIAZOLINES AND THIAZOLIDINE-2-THIONES

Diastereoisomeric 1-chloro-1-phenyl-2-isothiocyanatopropanes have been prepared.They reacted stereospecifically with CH3ONa, diethylamine, aniline and NaSH to give pure cis or trans-4,5-disubstituted Δ2-thiazolines and thiazolidine-2-thiones whose configuration was determined using the nuclear Overhauser effect.The preponderant conformation of diastereoisomeric 1-chloro-1-phenyl-2-isothiocyanatopropanes was estimated on the basis of coupling constants of vicinal protons.