436159-86-3Relevant academic research and scientific papers
Novel indolylindazolylmaleimides as inhibitors of protein kinase C-β: Synthesis, biological activity, and cardiovascular safety
Zhang, Han-Cheng,Derian, Claudia K.,McComsey, David F.,White, Kimberly B.,Ye, Hong,Hecker, Leonard R.,Li, Jian,Addo, Michael F.,Croll, Diane,Eckardt, Annette J.,Smith, Charles E.,Li, Quan,Cheung, Wai-Man,Conway, Bruce R.,Emanuel, Stuart,Demarest, Keith T.,Andrade-Gordon, Patricia,Damiano, Bruce P.,Maryanoff, Bruce E.
, p. 1725 - 1728 (2007/10/03)
Novel indolylindazolylmaleimides were synthesized and examined for kinase inhibition. We identified low-nanomolar inhibitors of PKC-β with good to excellent selectivity vs other PKC isozymes and GSK-3β. In a cell-based functional assay, 8f and 8i effectiv
BISINDOLYL-MALEIMID DERIVATIVES AS KINASE INHIBITORS
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Page 49-51, (2010/02/04)
The present invention is directed to novel substituted pyrroline compounds of Formula (I) wherein R1 is selected from the group consisting of a pyridinyl-R5, pyrimidinyl-R5, pyrazinyl-R5, furyl-R5, thienyl-R5, benzofuryl-R5, benzothienyl-R5, quinolinyl-R5 and isoquinolinyl-R5 ring attached to the indole nitrogen atom via a ring carbon atom;useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder such as cardiovascular, inflammatory, immunological, dermatological, oncological, CNS disorders and diabetes.
SUBSTITUTED PYRROLINES AS KINASE INHIBITORS
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Page 65, 66, (2008/06/13)
The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
