438035-30-4

Upstream product

• 65-85-0 benzoic acid 
• 219562-56-8 D-4,5-O-(1-methylethylidene)-3,6-bis-O-(phenylmethyl)-myo-inositol 
• 371155-62-3 (3aR,4S,7S,7aR)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol diacetate 
• 266682-75-1 (3aR,4S,7S,7aR)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-di-O-benzyl-2,3-benzodioxole-4,7-diol 
• 100-39-0 benzyl bromide 
• 371155-65-6 (3aR,4S,7S,7aR)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol 

Downstream Products

• 618072-72-3 C₃₇H₃₆O₈ 
• 618881-53-1 Phosphoric acid dibenzyl ester (3aR,4R,5S,6S,7R,7aR)-4,7-bis-benzyloxy-6-(bis-benzyloxy-phosphoryloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-yl ester 
• 618072-74-5 C₂₀H₂₀O₈ 
• 618072-70-1 Benzoic acid (1R,2R,3S,4S,5R,6S)-2,5-bis-benzyloxy-3,4,6-trihydroxy-cyclohexyl ester 
• 618072-68-7 (3aR,4S,5R,6R,7S,7aR)-4,7-Bis-benzyloxy-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol 

Relevant academic research and scientific papers

Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase

scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P2, scyllo-I(1,2,4)P3, scyllo-I(1,2,3,4)P4. We her

Facile syntheses of all possible diastereomers of conduritol and various derivatives of inositol stereoisomers in high enantiopurity from myo-inositol

Phosphoinositide-based signaling processes are crucially important in intracellular signal transduction events. Inositol phosphate analogues have been useful in probing the structure-activity relationships between inositol phosphates and biomacromolecules, and in studying biological functions of newly found inositol phosphates. Thus, a systematic and ready access to inositol stereoisomers is highly desirable. And practical and convenient syntheses of conduritols and related compounds are also important because of their biological activities and their synthetic utilities in the preparation of other bioactive molecules. We herein report the first syntheses of all possible diastereomers of conduritol and various derivatives of eight inositol stereoisomers in high enantiopurity from myo-inositol, which involve efficient enzymatic resolution of the intermediates conduritol B and C derivatives, followed by oxidation-reduction or the Mitsunobu reaction, and cis-dihydroxylation in stereo- and regioselective manners.