4381-37-7

Upstream product

• 626-55-1 3-Bromopyridine 
• 615-41-8 2-iodochlorobenzene 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 1056775-36-0 1-(bromoethynyl)-2-chlorobenzene 
• 1379538-69-8 N-allyl-N-tert-butoxycarbonyl-(2-chlorophenyl)ethynylamine 
• 694-80-4 2-bromo-1-chlorobenzene 
• 89878-14-8 3-Diethylboranylpyridine 
• 1120-90-7 3-iodopyridine 
• 108-90-7 chlorobenzene 

Downstream Products

• 712344-00-8 5-(2-chlorophenyl)-1,2,3,6-tetrahydro-1-methylpyridine 
• 712343-67-4 2-[5-(2-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one 
• 485385-74-8 3-(2-ethynylphenyl)pyridine 

Relevant academic research and scientific papers

De novo synthesis of 1,4-dihydropyridines and pyridines

An efficient and general method for the synthesis of 1,4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available N-allyl-ynamides.

Intramolecular carbolithiation of N-allyl-ynamides: An efficient entry to 1,4-dihydropyridines and pyridines - Application to a formal synthesis of sarizotan

We have developed a general synthesis of polysubstituted 1,4-dihydropyridines and pyridines based on a highly regioselective lithiation/6-endo-dig intramolecular carbolithiation from readily available N-allyl-ynamides. This reaction, which has been successfully applied to the formal synthesis of the anti-dyskinesia agent sarizotan, further extends the use of ynamides in organic synthesis and further demonstrates the synthetic efficiency of carbometallation reactions.

Synthesis of Vinylphenylpyridine and Living Anionic Polymerization

Provided are a vinyl-biphenylpyridine monomer and a polymer thereof. More particularly, the present invention provides a vinyl-biphenylpyridine monomer having a side chain of pyridine or phenylpyridine as a functional group, a homopolymer of which molecul

SYNTHESIS OF VINYLPHENYLPYRIDINE AND LIVING ANIONIC POLYMERIZATION

Provided are a vinyl-biphenylpyridine monomer and a polymer thereof. More particularly, the present invention provides a vinyl-biphenylpyridine monomer having a side chain of pyridine or phenylpyridine as a functional group, a homopolymer of which molecul

3-SUBSTITUTED-4-PYRIMIDONE DERIVATIVES

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof useful as a tau protein kinase 1 inhibitor:wherein X represents CH or nitrogen atom; R1 represents a C?1#191-C?12#191 alkyl group wh

Model reactions for the synthesis of azacorannulenes and related heteroaromatic compounds

4-(2-Ethynylphenyl)pyridine (10), 3-(2-ethynylphenyl)pyridine (11), 2-(2-trimethylsilylethynylphenyl)pyridine (26), and 3-ethynyl-2-phenylpyridine (13) were prepared from readily available pyridine precursors by standard coupling reactions. Pyrolysis of 10 at 810 °C/0.5 Torr provided benzo[f]isoquinoline (45) and the benzopentalene dimer 47. Pyrolysis of 11 (820 °C/0.5 Torr) afforded benzo[f]quinoline (50), benzo[h]i-soquinoline (52), and a mixture of isomers of 47. Pyrolysis of 13 (820 °C/0.3 Torr) provided benzo[h]quinoline (56) and the novel azulene derivative azuleno[1,2-b]pyridine (58). When 26 was desilylated by treatment with TBAF in THF/water, the unusual "dimerization" product 37 was produced; its structure was confirmed by X-ray structural analysis. The mechanisms of these transformations are discussed. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

THE PYRIDYL CATION AS A REACTIVE INTERMEDIATE IN THE PHOTOREACTION OF IODOPYRIDINES WITH BENZENES

The electrophilic behavior of the reactive entity in the photosubstitution of benzenes with 2-iodopyridine was found to be ascribable to the intermediary 2-pyridyl cation, rather than the electrophilic 2-pyridyl radical.

A CONVENIENT SYNTHESIS OF 3-ARYLPYRIDINES BY THE PALLADIUM CATALYZED COUPLING REACTION OF DIETHYL(3-PYRIDYL)BORANE WITH ARYL HALIDES

The utilization of heteroarylborane to the preparation of a variety of 3-arylpyridines by the palladium catalyzed cross coupling reaction between diethyl(3-pyridyl)borane and aryl halides in the presence of bases is described.