4385-05-1

Basic information

• Product Name: 4-[2-(Dimethylamino)ethyl]morpholine
• Synonyms: 4-Morpholineethanamine, N,N-dimethyl-;N,N-Dimethyl-2-(4-morpholinyl)ethanamine;n,n-dimethyl-4-morpholineethanamin;N,N-Dimethyl-4-morpholineethanamine;4-[2-(DIMETHYLAMINO)ETHYL]MORPHOLINE;4-DIMETHYLAMINE ETHYLMORPHOLINE;4-(2-(DIMETHYLAMINO)ETHYL)MORPHOLINE 9&;N,N-Dimethylmorpholine-4-ethanamine
• CAS NO: 4385-05-1
• Molecular Formula: C₈H₁₈N₂O
• Molecular Weight: 158.24
• EINECS: 224-492-3
• Mol File: 4385-05-1.mol

Chemical Properties

• Boiling Point: 93-94 °C20 mm Hg(lit.)
• Flash Point: 168 °F
• Appearance: /
• Density: 0.925 g/mL at 25 °C(lit.)
• Vapor Pressure: 3 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.4582(lit.)
• Storage Temp.: 2-8°C
• PKA: 9.41±0.28(Predicted)
• CAS DataBase Reference: 4-[2-(Dimethylamino)ethyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(Dimethylamino)ethyl]morpholine(4385-05-1)
• EPA Substance Registry System: 4-[2-(Dimethylamino)ethyl]morpholine(4385-05-1)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 4385-05-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-[2-(Dimethylamino)ethyl]morpholine is used as a reagent in organic synthesis for the preparation of various pharmaceuticals and agrochemicals, leveraging its unique chemical properties to facilitate the synthesis of complex organic molecules.
Used as a Solvent:
In the Chemical Industry, 4-[2-(Dimethylamino)ethyl]morpholine is utilized as a solvent in a variety of chemical reactions, providing a medium that supports the desired chemical transformations and improves the efficiency of the processes involved.

InChI:InChI=1/C8H18N2O/c1-9(2)3-4-10-5-7-11-8-6-10/h3-8H2,1-2H3

Upstream product

• 3240-94-6 N-(2-chlorethyl)morpholine 
• 124-40-3 dimethyl amine 
• 2038-03-1 4-(2-AMINOETHYL)MORPHOLINE 
• 67-56-1 methanol 
• 123091-15-6 2-dimethylamino ethanol p-toluene sulfonate 
• 110-91-8 morpholine 
• 74927-38-1 2,2'-diethylene glycol sulfonate 
• 108-00-9 N,N-dimethylethylenediamine 

Relevant articles and documents

Preparation method of 4-(2-(N, N-dimethylamino)ethyl)morpholine

The invention discloses a preparation method of 4-(2-(N, N-dimethylamino)ethyl)morpholine in the technical field of organic synthesis chemical industry, which comprises the following steps: dissolving2, 2'-diethylene glycol sulfonate and N, N-dimethylethylenediamine used as initial raw materials in a solvent, and carrying out cyclization reaction in the presence of an acid-binding agent to prepare 4-(2-(N, N-dimethylamino)ethyl)morpholine, the acid-binding agent is one of triethylamine, sodium hydroxide, sodium bicarbonate, sodium carbonate and potassium carbonate, the solvent is one of dimethyl sulfoxide, N, N-dimethyl formamide, N, N-dimethyl acetamide and tetrahydrofuran, the reaction temperature is 60 DEG C to 80 DEG C, and the reaction time is 6-9 hours. The method is mild in reaction condition and simple to operate, and has good popularization and application values, the obtained target product has huge application value in the aspects of chemical pharmacy, pesticides, organic synthesis and the like.

Method for synthesizing 4 - (2 - (N, N - dimethylamino) ethyl) morpholine (by machine translation)

The invention discloses a synthesis 4 - (2 - (N. The process. N- dimethylamino) ethyl) morpholine. Belong to fine chemical industry technical field. The technical scheme is: taking toluene as a solvent, N, N - dimethylethanolamine and p-toluenesulfonic acid under 110~120 °C heating reflux to carry out esterification reaction, and N, N - dimethylethanolamine p tosylate; N, N - dimethylethanolamine on tosylate reacts with morpholine, and the resulting reaction mixture is subjected to rectification to obtain a pure product. The method is cheap and easily available in raw materials, simple, mild, mild in reaction conditions, simple, high in yield, reusable, and capable of reducing cost. It is important that reaction process does not produce strong irritant gas, has reduced operating workman's health hazard greatly, does not need special corrosion-resistant equipment simultaneously, is favorable to the industrial production. (by machine translation)

Well-Defined Phosphine-Free Iron-Catalyzed N-Ethylation and N-Methylation of Amines with Ethanol and Methanol

An iron(0) complex bearing a cyclopentadienone ligand catalyzed N-methylation and N-ethylation of aryl and aliphatic amines with methanol or ethanol in mild and basic conditions through a hydrogen autotransfer borrowing process is reported. A broad range of aromatic and aliphatic amines underwent mono- or dimethylation in high yields. DFT calculations suggest molecular hydrogen acts not only as a reducing agent but also as an additive to displace thermodynamic equilibria.