4396-13-8

Basic information

• Product Name: 2,4,6-trihydroxyisophthalaldehyde
• Synonyms: 2,4,6-trihydroxyisophthalaldehyde;2,4-diforMyl phloroglucinol;Diformylphloroglucinol
• CAS NO: 4396-13-8
• Molecular Formula: C₈H₆O₅
• Molecular Weight: 182
• EINECS: -0
• Mol File: 4396-13-8.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2,4,6-trihydroxyisophthalaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-trihydroxyisophthalaldehyde(4396-13-8)
• EPA Substance Registry System: 2,4,6-trihydroxyisophthalaldehyde(4396-13-8)

Safety Data

• Hazardous Substances Data: 4396-13-8(Hazardous Substances Data)

Usage

Uses

Diformylphloroglucinol is an impurity in the synthesis of Hirsutidin Chloride (H356800), which is an anthocyanidin found in the Madagascar Periwinkle (Catharanthus Roseus). Hirsutidin Chloride can be used in the preparation of plant based compounds to lower LDL cholesterol.

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 26103-97-9 phloroisovalerophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 96573-43-2 1,3-diformyl-5-(3-methyl-butyryl)-2,4,6-trihydroxybenzene 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 

Downstream Products

• 1253907-13-9 C₂₆H₄₈N₂O₉Si₂ 
• 1400992-03-1 2,4,6-trihydroxy-5-((2-oxoazepan-1-yl)methyl)isophthalaldehyde 
• 1400992-10-0 1-(2,4,6-trihydroxy-3,5-diformyl-benzyl)piperidin-2-one 
• 1254173-26-6 (+)-psiguadial B 
• 94632-38-9 1,3-Dihydroxy-5-methoxy-2,4-dimethyl-benzol 
• 4463-02-9 2,4-dimethylbenzene-1,3,5-triol 
• 84633-27-2 Dimethylphlorobutyrophenone 

Relevant articles and documents

Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation

Inspired by the diversity-oriented synthesis, some novel formyl phloroglucinol meroterpenoids were synthesized via biomimetic synthesis using essential oils. Eight of them were demonstrated with good in vitro fungicidal activity against Candida albicans a

Total Syntheses of 4′,6′-Dimethoxy-2'-Hydroxy-3′,5′-Dimethylchalcone Derivatives

Chalcone derivatives afford several pharmacological activities. However, a general synthetic method for 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) derivatives has not been reported thus far. To address this, the preparation of 4',6'-dimethoxy-2'-hydroxy-3',5'-dimethylchalcone (MDMC) derivatives, modified compounds of DMC, in excellent overall yields is reported herein. These compounds have recently attracted growing attention due to their various pharmacological activities. Di-O-methyl-dimethylphloroacetophenone, the key intermediate containing the B-ring moiety, was fabricated by four efficient reaction steps from commercially available phloroglucinol in a 50.1% isolated yield overall. Our synthetic route, which constructs the chalcone skeleton in the final stage via a Claisen–Schmidt condensation of the key intermediate with the desired benzaldehyde derivative, can rapidly produce a vast library of DMC derivatives.

DIMETHYLCHALCONE DERIVATIVES AND PREPARATION METHOD THEREOF

The present invention relates to a dimethalcone (DMC) derivative and a method for producing the same. A compound according to an embodiment of the present invention is represented by chemical formula I: [Chemical Formula I]. In Formula I, R1, R2, and R3 are the same as or different from each other, R1 is a hydroxy group or a methoxy group, R2, and R3 are each independently hydrogen, deuterium, a nitro group, a hydroxyl group, a carbonyl group C1?C10, a nitro group, C1?C10 a hydroxyl group, an 'C2?C10 alkyloxy group', an aryloxy C2?C10 group, an aryloxy group, an alkylthioxy group, a silyl group, a boron group, an alkyl group or an C6?C20 aryl group. (C1?C10. The cycloalkyl group, alkenyl group, alkynyl group, aryl group, aralkyl group, aralkyl group, alkylaryl group, alkylamine group. The substituent may be substituted or unsubstituted with 1 or more substituents selected from the group consisting of an aralkylamine group, a heteroarylamine group, an arylamine group, an arylphosphine group, and a heterocyclic group.

HALOGEN-SUBSTITUTED DIMETHYLCHALCONE DERIVATIVES AND PREPARATION METHOD THEREOF

The present invention relates to dimethylchalcone (DMC) derivatives substituted with halogen and a method for producing the same. A compound according to an embodiment of the present invention is represented by chemical formula I: [Chemical Formula I]. In Formula I, R1 and R2 are the same as or different from each other, R1, and R2 are each independently selected from the group consisting of hydrogen, methoxy, and methoxy. R3, and R4 are each independently hydrogen or halogen elements, and when R3 is hydrogen, R4 R4 is any one selected from the group consisting of halogen elements R3.