(R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide

Base Information

• Chemical Name: (R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide
• CAS No.: 439695-63-3
• Molecular Formula: C₁₇H₂₀ClNOS
• Molecular Weight: 321.871
• Mol file: 439695-63-3.mol

Synonyms:(R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide

Chemical Property of (R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide

There total 7 articles about (R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-Chlorophenylboronic acid (1679-18-1) + (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide (186249-76-3) → (RS,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide (439695-63-3)

Guidance literature:

With [Rh(κ²-O,O-acetylacetonato)(COE)₂]; o-phenylenebis(diphenylphosphine); In 1,4-dioxane; at 70 ℃; for 10h;

DOI:10.1021/ja044003d

Reference yield: 65.0%

phenylmagnesium bromide + (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide (336105-23-8) → (R(S))-N-((R)-1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropane-2-sulfinamide (439695-64-4) + (RS,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide (439695-63-3)

Guidance literature:

In diethyl ether; at -20 ℃;

DOI:10.1016/S0040-4039(01)02294-8

Reference yield:

phenyllithium (591-51-5) + (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide (336105-23-8) → (R(S))-N-((R)-1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropane-2-sulfinamide (439695-64-4) + (RS,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide (439695-63-3)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; at -78 ℃; Title compound not separated from byproducts;

DOI:10.1016/S0040-4039(01)02294-8

upstream raw materials:

(R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide

phenyllithium

(4-chlorphenyl)magnesium bromide

(R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide

Downstream raw materials:

(S)-4-chloro-α-phenyl-benzenemethanamine

(α¹S)-4-chloro-α-phenyl-benzenemethanamine hydrochloride

(S)-(-)-cetirizine ethyl ester

1-[(S)-(4-Chloro-phenyl)-phenyl-methyl]-4-(toluene-4-sulfonyl)-piperazine