4397-16-4

Usage

Appearance

Colorless liquid

Odor

Characteristic pungent odor

Aliases

Cumene hydroperoxide

Main Use

Chemical intermediate in the production of acetone and phenol

Industrial Applications

Used as a radical initiator in propylene oxide manufacture

Laboratory Applications

Utilized as a reagent in organic synthesis

Health Hazards

Potential skin and eye irritation upon exposure

Respiratory Effects

May have harmful effects on the respiratory system

Upstream product

• 50-00-0 formaldehyd 
• 88-69-7 2-(1-methylethyl)phenol 
• 67372-96-7 3-isopropylsalicylaldehyde 

Downstream Products

• 214077-01-7 8-Isopropyl-2,2-dimethyl-4H-benzo[1,3]dioxine 
• 80865-61-8 (3-isopropyl-2-methoxyphenyl)methanol 
• 1433061-10-9 C₁₆H₂₈O₂Si 
• 1433061-70-1 C₁₅H₂₂O₄ 
• 1433061-40-5 C₂₁H₃₆O₄Si 
• 1433062-00-0 (2R)-ethyl 2-(2’-bromomethyl-6’-isopropylphenoxy)propanoate 

Relevant academic research and scientific papers

Deconjugative α-Alkylation of Cyclohexenecarboxaldehydes: An Access to Diverse Terpenoids

A general and efficient method for the deconjugative α-alkylation of α,β-unsaturated aldehydes promoted by a synergistic effect between tBuOK and NaH, which considerably increases the reaction rate under mild conditions, is reported. The β,γ-unsaturated aldehyde, resulting from the α-alkylation, is transformed in high yield into the corresponding allyl acetate via a lead(IV) acetate-mediated oxidative fragmentation. This strategy could be used for the construction of the carbon skeleton of a wide variety of alkyl or arylterpenoids.

Asymmetric induction via short-lived chiral enolates with a chiral C-O axis

A novel method has been developed for the asymmetric cyclization of alkyl aryl ethers. The reactions were assumed to proceed via short-lived chiral enolate intermediates with a chiral C-O axis to give cyclic ethers with tetrasubstituted carbon in up to 99% ee. The half-life of racemization of the chiral enolate intermediate was roughly estimated to be ～1 s at -78 C.

PHOSPHONIC ACID DERIVATES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS

The invention relates to 2-phenyl-pyrimidine derivatives containing a phosphonic acid motif and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. (I).

Investigation of Mn(III)-based oxidative free radical cyclization reactions toward the synthesis of triptolide: The effects of lanthanide triflates and substituents on stereoselectivity

Mn(III)-mediated oxidative free radical cyclization reactions are useful for construction of polycyclic compounds. In the total synthesis of triptolide (3) and its related compounds, construction of tricyclic skeletons 4 and 5 was achieved by the Mn(OAc)