440633-77-2

Upstream product

• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 58202-26-9 2-benzyl-3-oxo-2,3-dihydrobenzo[b]furan 
• 4265-14-9 2-benzylbenzofuran 
• 81289-36-3 2-(2-nitro-3-phenylpropyl)phenol 
• 75318-34-2 3-oxo-2-phenylmethylidene-2,3-dihydrobenzo[b]furan 
• 100-52-7 benzaldehyde 
• 7169-34-8 3-oxo-2,3-dihydrobenzo[b]furan 
• 773837-37-9 sodium cyanide 
• 6125-24-2 2-Phenylnitroethane 
• 90-02-8 salicylaldehyde 

Relevant academic research and scientific papers

Syntheses of 2-Benzylbenzofuran Derivatives and 2-Aryl-nitrochroman Derivatives from Nitroalkene Precursors

Simple and straightforward methods for the synthesis of 2-benzylbenzofuran, 3-substituted 2-benzylbenzofuran, and 2-aryl-nitrochroman derivatives are described. Benzofurans were generated from nitroalkenes by reduction with NaBH4 followed by a Nef reaction and acid-mediated cyclization, whereas 3-substituted 2-benzylbenzofurans were prepared from nitroalkenes by reactions with Grignard reagents followed by a Nef reaction and an acid-mediated cyclization in a one-pot process. The synthesis of chromans involved a Knoevenagel condensation and the 1,4-diazabicyclo[2.2.2]octane (DABCO) assisted cyclization of β-(2-hydroxyphenyl)-nitroethanes and benzaldehydes, also in a one-pot process. Simple and convenient methods for the synthesis of 2-benzylbenzofuran, 3-substituted 2-benzylbenzofuran, and 2-aryl-nitrochroman derivatives are described.

Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT2 melatonin receptor selective ligands

A series of N-(2-phenylbenzofuran-3-yl) ethyl amide and N-(2-arylalkylbenzofuran-3-yl) ethyl amide derivatives were synthesized and evaluated as melatonin receptor ligands. The affinity of each compound for the two MT1 and MT2 melato