58202-26-9Relevant academic research and scientific papers
Design, synthesis and biological activities of dihydroaurones
VENKATESWARLU, SOMEPALLI,MURTY, GANDROTU NARASIMHA,SATYANARAYANA, MEKA,SIDDAIAH, VIDAVALUR
, p. 1396 - 1402 (2021/06/09)
To widen aurones applicability in achromatic food and cosmetic applications, a series of dihydroaurones were designed to mimic natural aurones as well as synthetic aurones. Dihydroaurones have been synthesized from the corresponding aurones by hydrogenation. These dihydroaurones and their corresponding aurones were screened for antioxidant, anti-inflammatory and tyrosinase enzyme inhibitory activity. Synthesized dihydroaurones (3b-f) displayed superior antioxidant activity in superoxide free radical scavenging assay than the standard gallic acid. Dihydroaurones (3b-f) also exhibited significant tyrosinase enzyme inhibitory activity and two dihydroaurones (3h, 3j) showed promising 5-lipoxygenase inhibitory activity.
Optically Active Flavaglines-Inspired Molecules by a Palladium-Catalyzed Decarboxylative Dearomative Asymmetric Allylic Alkylation
Cao, Meng-Yue,Gan, Kang-Ji,Gao, Wei,Hong, Xin,Huang, Yu-Hao,Lao, Zhi-Qi,Liu, Juan,Lu, Hai-Hua,Ma, Bin-Jie,Wang, Hongliang,Wang, Huaimin,Wang, Jing,Xing, Kuan
supporting information, p. 12039 - 12045 (2020/08/06)
With the aid of a class of newly discovered Trost-type bisphosphine ligands bearing a chiral cycloalkane framework, the Pd-catalyzed decarboxylative dearomative asymmetric allylic alkylation (AAA) of benzofurans was achieved with high efficiency [0.2-1.0 mol% Pd2(dba)3/L], good generality, and high enantioselectivity (>30 examples, 82-99% yield and 90-96% ee). Moreover, a diversity-oriented synthesis (DOS) of previously unreachable flavaglines is disclosed. It features a reliable and scalable sequence of the freshly developed Tsuji-Trost-Stoltz AAA, a Wacker-Grubbs-Stoltz oxidation, an intra-benzoin condensation, and a conjugate addition, which allows the efficient construction of the challenging and compact cyclopenta[b]benzofuran scaffold with contiguous stereocenters. This strategy offers a new avenue for developing flavagline-based drugs.
Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT2 melatonin receptor selective ligands
Wallez, Valérie,Durieux-Poissonnier, Sophie,Chavatte, Philippe,Boutin, Jean A.,Audinot, Valérie,Nicolas, Jean-Paul,Bennejean, Caroline,Delagrange, Philippe,Renard, Pierre,Lesieur, Daniel
, p. 2788 - 2800 (2007/10/03)
A series of N-(2-phenylbenzofuran-3-yl) ethyl amide and N-(2-arylalkylbenzofuran-3-yl) ethyl amide derivatives were synthesized and evaluated as melatonin receptor ligands. The affinity of each compound for the two MT1 and MT2 melato
Synthesis of β-keto-phosphotriesters using functionalized diazoketones
Gefflaut,Perie
, p. 29 - 33 (2007/10/02)
Convenient substitution (Ac) on the heteroatom in diazo ketones as in compounds 6, 8 or 10, prevents the classical cyclisation reaction and allows intermolecular addition; the reaction is applied to phosphorylation (reaction 1).
