441012-04-0

Basic information

• Product Name: Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-
• CAS NO: 441012-04-0
• Molecular Formula: C20H19N2O3P
• Molecular Weight: 366.356
• Mol File: 441012-04-0.mol

Chemical Properties

• CAS DataBase Reference: Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-(441012-04-0)
• EPA Substance Registry System: Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-(441012-04-0)

Safety Data

• Hazardous Substances Data: 441012-04-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 1079-66-9 chloro-diphenylphosphine 
• 932-90-1 Benzaldoxime 
• 75-52-5 nitromethane 
• 98837-46-8 N-benzylidenediphenylphosphinamide 

Downstream Products

• 137581-63-6 (S)-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 
• 441012-07-3 C₂₀H₂₁N₂OP 

Relevant articles and documents

Enantioselective Aza-Henry Reaction Catalyzed by a Bifunctional Organocatalyst

(Matrix presented) The aza-Henry reaction of imines with nitroalkanes was promoted by chiral thiourea with an N,N-dimethylamino group to give β-nitroamines with good enantioselectivity. Various N-protected imines were examined as substrates. N-Phosphinoyl

Iron-Catalyzed Asymmetric Nitro-Mannich Reaction

The first enantioselective addition of nitroalkanes to imines (nitro-Mannich reaction), mediated by an iron(II) catalyst assembled by a hindered hydroxyethyl-pybox ligand, is described. This valuable carbon-carbon bond-forming reaction proceeds smoothly at room temperature to afford enantioenriched β-nitro amines in good yields and high enantioselectivity, up to 98% with unprecedentedly low iron catalyst loading (5 mol %).

The amino thiourea-catalyzed asymmetric nucleophilic reactions

Bifunctional amino thiourea-catalyzed asymmetric additions of several nucleophiles into electron-deficient unsaturated compounds such as nitroolefins, α,β-unsaturated imides, imines, and azodicarboxylates are described. We discovered that bifunctional thi

Reaction of nitroorganic compounds using thiourea catalysts anchored to polymer support

Immobilization of chiral thiourea catalyst was studied. The PEG-bound thiourea showed better catalytic activity than those of the carboxypolystyrene HL resin-bound and TentaGel carboxy resin-bound thioureas. In the presence of PEG-bound thiourea, Michael and tandem Michael reactions of trans-β- nitrostyrene proceeded enantioselectively. Georg Thieme Verlag Stuttgart.

Catalytic asymmetric syntheses of ICI-199441 and CP-99994 using nitro-Mannich reaction

Catalytic asymmetric syntheses of ICI-199441 and CP-99994 were achieved using the nitro-Mannich reaction as a key step.