4411-93-2

Upstream product

• 37791-41-6 4-ethylidene-2-phenyl-5-oxazolone 
• 857780-50-8 N-benzoylthreonine 
• 27696-01-1 (2S,3R)-threo-N-benzoyl-threonine 
• 7469-23-0 N-benzoyl-DL-threonine 
• 7469-23-0 N-benzoyl-DL-allothreonine 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 105909-91-9 methyl 2-benzoylamino-3-methylacrylate 
• 5468-52-0 N-benzoyl-2-aminobutyric acid 
• 103862-68-6 2-benzoylamino-3-chloro-crotonic acid 
• 34023-32-0 2-benzoylamino-crotonic acid ethyl ester 
• 37791-41-6 4-ethylidene-2-phenyl-5-oxazolone 
• 600-18-0 2-Oxobutyric acid 
• 5221-67-0 5-methyl-2-phenyloxazole 
• 18735-74-5 5-methyl-2-phenyloxazole-4-carboxylic acid 
• 100063-41-0 methyl 5-methyl-2-phenyloxazole-4-carboxylate 
• 105907-17-3 2-benzoylamino-3-chloro-crotonic acid methyl ester 

Relevant academic research and scientific papers

Thionation of N-acylthreonine and its methyl ester with Lawesson's reagent: Synthesis of 5-oxazolones, 5-thiazolones and thiazolines

The treatment of N-acylthreonine (1) with Lawesson's reagent [LR: 2,4-bis(p-methoxyphenyl)-1,3,2,4-dithiaphosphetane 2,4-disulfide] afforded 5-oxazolones (2) in moderate yields, along with 5-thiazolones (3). On the other hand, N- acylthreonine methyl este

Michael Addition of Amines and Thiols to Dehydroalanine Amides: A Remarkable Rate Acceleration in Water

In water, the rate of Michael addition of amines and thiols to dehydroalanine amides was greatly accelerated, leading to shorter reaction times and higher yields. The scope of the new conditions was tested with a range of amines, thiols, and dehydroalanine amides. The ease and efficiency of this method provides an attractive route to the synthesis of natural and unnatural amino acid derivatives.