4427-97-8

Usage

Uses

Used in Pharmaceutical Industry:
Dicyclohexyl carbonate is used as a reagent for the synthesis of colon-specific reduction-sensitive polymers. This application is particularly important in the development of targeted drug delivery systems, as these polymers can release their drug payloads specifically in the colon upon reduction. This targeted approach can improve the efficacy and reduce the side effects of certain medications.

InChI:InChI=1/C13H22O3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h11-12H,1-10H2

Upstream product

• 75-44-5 phosgene 
• 108-93-0 cyclohexanol 
• 60-29-7 diethyl ether 
• 925-90-6 ethylmagnesium bromide 
• 105-58-8 Diethyl carbonate 
• 201230-82-2 carbon monoxide 
• 22096-22-6 sodium cyclohexanolate 
• 57-13-6 urea 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 124-38-9 carbon dioxide 
• 120-80-9 benzene-1,2-diol 
• 2171-74-6 1,3-benzodioxol-2-one 
• 69741-52-2 bisphenol A 
• 67-66-3 chloroform 

Relevant academic research and scientific papers

Direct synthesis of a jet fuel range dicycloalkane by the aqueous phase hydrodeoxygenation of polycarbonate

For the first time, propane-2,2-diyldicyclohexane, a jet fuel range C15dicycloalkane was directly produced by the aqueous phase hydrodeoxygenation (APHDO) of polycarbonate (PC). Among the investigated catalyst systems, the mixture of Rh/C and H-USY (denoted as Rh/C + H-USY) exhibited the best performance. Over it, a high yield of propane-2,2-diyldicyclohexane (94.9%) was achieved from the APHDO of pure PC pellets after a reaction was carried out at 473 K and 3.5 MPa H2for 12 h. The Rh/C + H-USY catalyst was stable under the investigated conditions. No evident deactivation was observed during three repeated cycles. When we used a chopped DVD disk (a representative of real PC wastes) as the substrate, a high yield (86.9%) of propane-2,2-diyldicyclohexane was obtained under the same reaction conditions. The propane-2,2-diyldicyclohexane as obtained had a high density (0.92 g mL?1) and a high volumetric net heat of combustion (39.6 MJ L?1). As a potential application, it can be blended into jet fuels to improve the range and payload of airplanes.

CARBONATE DERIVATIVE PRODUCTION METHOD

The objective of the present invention is to provide a method for producing a carbonate derivative in a safe and efficient manner. The method for producing a carbonate derivative according to the present invention is characterized in comprising irradiating light on a composition containing a C1-4 halogenated hydrocarbon having one or more kinds of halogen atoms selected from the group consisting of a chlorine atom, a bromine atom and an iodine atom, a nucleophilic functional group-containing compound and the specific base in the presence of oxygen.

The design of efficient carbonate interchange reactions with catechol carbonate

Catechol carbonate (CC) has been investigated as an innovative and highly active reactant for carbonate interchange reactions (CIRs). Under mild conditions (atmospheric pressure, and 60-80°C), the selective synthesis of symmetric aliphatic carbonates (ROCO2R) has been achieved by the reaction of a slight excess of both primary and secondary alcohols with CC in the presence of NaOMe or MgO as a catalyst. Quantitative conversions have been reached in only 1 hour and products have been isolated in yields of up to 58% for dibutylcarbonate. Of note is that the reaction of glycerol with CC also proceeded under similar conditions (40-60°C, 1 atm) to afford glycerol carbonate (96-98%). The comparison of the reactivity of CC with that of conventional dialkyl carbonates, including dimethyl carbonate (DMC) and ethylene carbonate (EC), proved the superior performance of CC in all the investigated CIR processes. Accordingly, a mechanism has been formulated based on the leaving group ability of a catecholate anion originating from CC.

SINGLE-POT SYNTHESIS OF DIALKYL CARBONATES USING CATALYST FROM NATURAL RESOURCE

The present invention relates to a single-pot method for preparing dialkyl carbonates, the method comprises reaction of alkylene oxide with aliphatic or cyclic aliphatic alcohol, using wood ash catalyst, under CO2 pressure and heating the reaction mixture thereof to obtain dialkyl carbonates.

Carbonate, acetate and phenolate phosphonium salts as catalysts in transesterification reactions for the synthesis of non-symmetric dialkyl carbonates

Methyl trioctylphosphonium methyl carbonate [P8881] +[MeOCO2]- was prepared by the alkylation of trioctyl phosphine with the non-toxic dimethyl carbonate. This salt was a convenient source to synthesize different ionic liquids where the methyl trioctylphosphonium cation was coupled to weakly basic anions such as bicarbonate, acetate, and phenolate. At 90-220 °C, all these compounds [P8881]+X-; X = MeOCO2; HOCO 2; AcO; PhO were excellent organocatalysts for the transesterification of dimethyl and diethyl carbonate with primary and secondary alcohols, including benzyl alcohol, cyclopentanol, cyclohexanol, and the rather sterically hindered menthol. Conditions were optimized to operate with very low catalyst loadings up to 1 mol% and to obtain non-symmetric dialkyl carbonates (ROCO2R′; R = Me, Et) with selectivity up to 99% and isolated yields >90%. The catalytic performance of the investigated ionic liquids was discussed through a cooperative mechanism of simultaneous activation of both electrophilic and nucleophilic reactants.

Lanthanum(III) isopropoxide catalyzed chemoselective transesterification of dimethyl carbonate and methyl carbamates

A practical transesterification of less reactive dimethyl carbonate and much less reactive methyl carbamates with primary (1°), secondary (2°), and tertiary (3°) alcohols was established with the use of a lanthanum(III) complex, which was prepared in situ from lanthanum (III) isopropoxide (3 mol %) and 2-(2-methoxyethoxy)ethanol (6 mol %). In particular, corresponding carbonates and carbamates obtained were of synthetic utility from the viewpoint of the selective protection and/or deprotection of 1°-, 2°-, and 3°-alcohols.

METHOD OF RECOVERING BISPHENOL A FROM WASTE PLASTIC

PROBLEM TO BE SOLVED: To provide a method of recovering bisphenol A which can recover low purity bisphenol A as high purity bisphenol A. SOLUTION: The method of recovering bisphenol A which comprises a main reaction step 2 of reacting phenol with acetone in the presence of an acidic catalyst to obtain a reaction product containing bisphenol A, a distillation and separation step 4 of distilling the reaction product to separate a vaporized product, a crystallization and recovery step 6 of separating the reaction product separated from the vaporized product into an adduct crystal of bisphenol A and phenol and a mother liquor and recovering the bisphenol A from the adduct crystal, and a circulation step 8 of recirculating the separated liquor to the main reaction step has a mixing step 10 of mixing a crude liquor containing low purity bisphenol A recovered from a decomposition product obtained by the thermal or chemical decomposition of a waste plastic into the mother liquor separated from the adduct crystal or the reaction product separated from the vaporized product.

PROCESS FOR PRODUCING CARBONIC ESTER

A method for producing a carbonic ester, comprising (1) performing a reaction between an organometal compound having a metal-oxygen-carbon linkage and carbon dioxide to obtain a reaction mixture containing a carbonic ester formed by the reaction, (2) separating the carbonic ester from the reaction mixture to obtain a residual liquid, and (3) reacting the residual liquid with an alcohol to form an organometal compound having a metal-oxygen-carbon linkage and form water and removing the water from the organometal compound, wherein the organometal compound obtained in step (3) is recovered for recycle thereof to step (1).

Phenylimidazolidines containing nitrooxy or carbonyloxy groups

A subject of the invention is the products of formula (I): in which: R1and R2represent in particular cyano and trifluoromethyl, R3represents in particular alkyl, alkenyl or alkynyl, substituted in particular by nitrooxy or carbonyloxy, R4and R5represent in particular methyl optionally substituted by fluorine, X and Y represent in particular oxygen, as well as their salts and isomers.

Continuous manufacturing method for aromatic carbonates

To provide a method whereby aromatic carbonates can be manufactured continuously and efficiently by reacting dialkyl carbonate and an aromatic hydroxy compound. When reacting dialkyl carbonate and an aromatic hydroxy compound in the presence of a catalyst in a reactor, recovering dialkyl carbonate and aromatic hydroxy compound removed from the reactor, and returning it to the reaction system, at least one of the following refinement and recycling processes is conducted: [I] alcohols and alkyl aromatic ethers (anisoles) are separated and removed from the reaction mixture removed from the top of the reactor, and the dialkyl carbonate thus obtained is returned to the reaction system and [II] alkyl aromatic ethers are separated and removed from the reaction mixture removed from the bottom of the reactor and dialkyl carbonate and/or aromatic hydroxy compound are returned to the reaction system.