4430-75-5

Basic information

• Product Name: Octahydro-2H-pyrido[1,2-a]pyrazine
• Synonyms: octahydro-1H-pyrido[1,2-a]pyrazine;(^+)-1,4-Diazabicyclo[4.4.0]decane, 98+%
• CAS NO: 4430-75-5
• Molecular Formula: C₈H₁₆N₂
• Molecular Weight: 140.23
• Mol File: 4430-75-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 68-72℃/3mm
• Flash Point: 93.708 °C
• Appearance: /
• Density: 1.01 g/cm³
• Vapor Pressure: 0.129mmHg at 25°C
• Refractive Index: 1.526
• PKA: 9.80±0.20(Predicted)
• CAS DataBase Reference: Octahydro-2H-pyrido[1,2-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: Octahydro-2H-pyrido[1,2-a]pyrazine(4430-75-5)
• EPA Substance Registry System: Octahydro-2H-pyrido[1,2-a]pyrazine(4430-75-5)

Safety Data

• RIDADR: 3267
• HazardClass: IRRITANT
• PackingGroup: Ⅱ
• Hazardous Substances Data: 4430-75-5(Hazardous Substances Data)

Usage

General Description

Octahydro-2H-pyrido[1,2-a]pyrazine is a chemical compound with the molecular formula C6H12N2. It is a saturated bicyclic compound that contains a nitrogen heterocycle. Octahydro-2H-pyrido[1,2-a]pyrazine is known for its use in the synthesis of various pharmaceuticals and agrochemicals. It is also used in the production of flavors and fragrances due to its pleasant odor. Additionally, it has been studied for its potential use as an insect repellent. Octahydro-2H-pyrido[1,2-a]pyrazine is considered to be relatively stable and is not known to pose significant hazards to human health or the environment when handled and used properly.

InChI:InChI=1/C8H16N2/c1-2-5-10-6-4-9-7-8(10)3-1/h8-9H,1-7H2

Upstream product

• 37043-04-2 3,6,7,8,9,9a-hexahydro-2H-pyrido[1,2-a]pyrazine-1,4(3H,6H)-dione 
• 22990-77-8 C-piperidin-2-yl-methylamine 
• 131543-46-9 Glyoxal 
• 1049651-61-7 benzyl hexahydro-1H-pyrido[1,2-a]pyrazine-2(6H)-carboxylate 
• 113570-68-6 octahydro-pyrido[1,2-a]pyrazine; dihydrochloride 
• 155346-54-6 [(Piperidine-2-carbonyl)-amino]-acetic acid methyl ester; compound with trifluoro-acetic acid 
• 15862-72-3 ethyl pipecolate 
• 139579-84-3 1-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-piperidine-2-carboxylic acid ethyl ester 
• 15932-71-5 2H-octahydropyrido<1,2-a>pyrazin-1-one 
• 100368-23-8 1-(2-chloro-ethyl)-2-chloromethyl-pyrrolidine 

Downstream Products

• 338969-78-1 2-(1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine 
• 484676-05-3 ethyl 3-(octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)propionate 
• 917610-32-3 2-[1-(diphenylmethyl)azetidin-3-yl]octahydro-2H-pyrido[1,2-a]pyrazine 
• 508236-00-8 5-(3,4-Dimethoxybenzylamino)-2-(2-furyl)-8-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-ylmethyl)[1,2,4]triazolo[1,5-c]pyrimidine 
• 1035271-14-7 methyl 4-(1,3,4,6,7,8,9,9a-octahydropyrido[2,1-c]pyrazin-2-yl)benzoate 
• 1035269-90-9 5-(1,3,4,6,7,8,9,9a-octahydropyrido[2,1-c]pyrazin-2-yl)-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]pyrazine-2-carboxamide 
• 80276-17-1 (4-Amino-phenyl)-(octahydro-pyrido[1,2-a]pyrazin-2-yl)-methanone 
• 915722-90-6 4-(octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)phenylamine 

Relevant articles and documents

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.

6' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1—R4 A, B, D, E, and G are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

BICYCLIC NONANE AND DECANE COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY

Described herein are D4 receptor-selective compounds of the general formula: STR1 wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5-or 6-membered, homo-or heterocyclic rings;X 1 is selected from CH 2, O, NH, S, C=O, CH--OH, CH--N(C 1-4 alkyl) 2, C=CHCl, C= CHCN, N-C 1-4 alkyl, N-acetyl, SO 2 and SO;X. sub.2---is selected from N=, CH 2--, CH=, C(O)--, O--, and S--;n is 1 or 2;R 1 is selected from H and an amino acid side chain;R 2 is selected from H, OH, C 1-9 alkyl, C 1-9 alkoxy, and benzyloxy; andR 3 is selected from H, OH, halo, cyano, C 1-4 alkyl, C 1-4 alkoxy, phenoxy, benzyloxy, =O, =S, C 1-4 alkylsulfonyl, C 1-4 alkylsulfonyl, C 1-4 alkylthio, amino, and aminocarbonyl;and acid addition salts, solvates and hydrates thereof. Their use as ligands for dopamine receptor identification and in a drug screening program, and as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia, is also described.